TABLE 3

Orphan receptors

Gene symbols are those approved by the HUGO Gene Nomenclature Committee (http://www.genenames.org/) (Seal et al., 2011). Where the phenotype of the knockout mouse has been published, this is indicated: Further information can be obtained from the IUPHAR Database (http://www.iuphar-db.org/) (Sharman et al., 2011) and the Mouse Genome Database at Mouse Genome Informatics (Eppig et al., 2012).

Approved Human Gene SymbolKnockout MousePhenotype Reported
Class A
    BB3YesYes
    GPR15No
    GPR19YesYes
    GPR20YesNo
    GPR21YesNo
    GPR22YesYes
    GPR25No
    GPR26YesYes
    GPR27No
    GPR33aNo
    GPR37L1YesYes
    GPR42b,cNo
    GPR45No
    GPR50YesYes
    GPR52No
    GPR61YesNo
    GPR62No
    GPR63No
    GPR78Nobb
    GPR79cNodd
    GPR82YesYes
    GPR83YesNo
    GPR85YesYes
    GPR88YesYes
    GPR101No
    GPR135No
    GPR139No
    GPR141No
    GPR142No
    GPR146No
    GPR148bNo
    GPR149YesYes
    GPR150No
    GPR151YesNo
    GPR152No
    GPR153No
    GPR160No
    GPR161YesNo
    GPR162No
    GPR171No
    GPR173No
    GPR174No
    GPR176No
    GPR182No
    MAS1LbNo
    MRGPREYesYes
    MRGPRFNo
    MRGPRGNo
    MRGPRX3Nod
    MRGPRX4bNo
    OPN3No
    OPN5No
    P2RY8bNo
    TAAR2No
    TAAR3cNo
    TAAR4PcNo
    TAAR5No
    TAAR6No
    TAAR8No
    TAAR9No
Class B
    BAI2YesYes
    CELSR1YesYes
    CELSR2YesYes
    CELSR3YesYes
    ELTD1YesNo
    EMR1YesYes
    EMR2bNo
    EMR3bNo
    EMR4PcNo
    GPR64YesYes
    GPR97YesNo
    GPR98YesYes
    GPR110No
    GPR111No
    GPR112No
    GPR113No
    GPR114No
    GPR115No
    GPR116No
    GPR123No
    GPR124YesYes
    GPR125YesNo
    GPR126YesYes
    GPR128No
    GPR133No
    GPR144No
    GPR157No
    LPHN2No
Class C
    GPR156No
    GPR158No
    GPR179YesYes
    GPRC5AYesYes
    GPRC5BYesYes
    GPRC5CYesNo
    GPRC5DNo
  • a Pseudogene in most individuals.

  • b Gene absent in rats and mice.

  • c Pseudogene in man.