Endogenous Ligand | Official IUPHAR Nomenclature | Previous Nomenclature | Approved Human Gene Symbol | Knockout Mouse | Phenotype Reported |
---|---|---|---|---|---|
Chemerin (RARRES2, resolvin E1, TIG2) | Chemerin | CMKLR1 | CMKLR1 | Yes | Yes |
CXCL12 (SDF-1), CXCL11 (ITAC) | CXCR7 | CMKOR1 | CXCR7 | Yes | Yes |
Omega-3 fatty acids | FFA4 | GPR120/GPR129 | O3FAR1 | Yes | Yes |
Lactate | HCA1 | GPR81/GPR104 | HCAR1 | Yes | Yes |
d-β-Hydroxybutyrate | HCA2 | GPR109A | HCAR2 | Yes | Yes |
3-Hydroxyoctanoate | HCA3 | GPR109B | HCAR3a | No | |
LPA | LPA4 | GPR23 | LPAR4 | Yes | Yes |
LPA | LPA5 | GPR92/GPR93 | LPAR5 | Yes | Yes |
LPA | LPA6 | P2RY5 | LPAR6 | No | |
2-Oxoglutarate | Oxoglutarate | GPR91 | OXGR1 | No | |
Succinate | Succinate | GPR99 | SUCNR1 | Yes | Yes |
↵a Gene absent in mice.