TABLE 2

Summary of endpoints after prenatal tricyclic/tetracyclic antidepressant exposure in animals

DrugSpeciesDose (mg/kg per day)RouteExposureMaternal Serum Monitored for Drug Conc.5-HTNEDABehaviorCardioHealthEndpointReference
CLO, IPD, MNSRat10SCG6–G21No+++øP25De Ceballos et al., 1985b
AMIRat10SCG2–G21No+øP60Henderson et al., 1993
CLO, DSP, NOMRat10OGG6–G21No+P25Montero et al., 1990
AMIRat10SCG2–G21NoøøøP30, 60, 180Henderson et al., 1991
CLO, IPD, TNPRat10SCG6–G21NoøP25Montero et al., 1991
IMIRat15OGG8–G20No++++P14, 30Jason et al., 1981
IMIRat0, 5, 10SCG8–G20No+ø+øP1, 7Ali et al., 1986
IMIRatUnknownDWG0–P21NoøøP290Tonge, 1972, 1973
IMIRat0, 5, 10SCG8–G20Noø+øP4, 7Harmon et al., 1986
CLO, NOM, IPR, MNSRat10SCG6–G21No++P25De Ceballos et al., 1985a
DSPRat10SCG8–G20NoøøøP20Stewart et al., 1998
IMIRat5OGG14–G19No++P21Coyle, 1975
CLORat3, 10, 30IPG8–G21No++P35File and Tucker, 1983
DSP, MNS, VXRat1.25/5/10SCG8–G20No++P23, 60Cuomo et al., 1984
AMIRat10SCG2–G21No++P30Henderson et al., 1990
CLORat3DWG14–P2No+øP50, 110Rodríguez et al., 1983
IMIRat5OGG21–P25No+P25, 80Coyle and Singer, 1975a
CLORat7.5, 15IPG8–G21No+P32, P42File and Tucker, 1984
IMIRat5OGG14–G19Noø+P60Coyle and Singer, 1975b
DOX, IMIRat30IPVariedNo++P35–70Simpkins et al., 1985
AMIHamster75IPG8No+G15Beyer et al., 1984
IMIRat5, 15, 30SCG21–G21No+P1Singer and Coyle, 1973
IMIRat10IPG9–G11No+G21Swerts et al., 2010
IMIRat5SCG1–21No+, øP56, 90Fujii, 1997; Fujii and Ohtaki, 1985
IMIPrimate20–244OGVariedNoøNAHendrickx, 1975
  • +, Positive association; ø, null association; AMI, amitriptyline; CLO, clomipramine; DSP, deprenyl; DOX, doxepin; DSP, desipramine; DW, drinking water; G, gestation day; IMI, imipramine; IP, intraperitoneal; IPD, iprindole; MNS, mianserin; NOM, nomifensine; OG, oral gavage; P, postnatal day; SC, subcutaneous; TNP, tianeptine; VX, viloxazine.