Pharmacology of MAS-related G protein–coupled receptors A
MRGPRA subfamily members that have been assigned to a ligand are listed. All data were generated after recombinant MRGPR expression.
| Receptor | Ligand | EC50 | Readout | System | Reference |
|---|---|---|---|---|---|
| nM | |||||
| mMRGPRA1 | FMRFamide | 20 | calcium | HEK293-Gα15 | Dong et al., 2001 |
| NPFF | 200 | calcium | HEK293-Gα15 | Dong et al., 2001 | |
| hβ-Salusin | 300 | calcium | HEK293 | Wang et al., 2006b | |
| chloroquine | 300,000 | calcium | HEK293 | Liu et al., 2009 | |
| mMRGPRA4 | NPAF | 60 | calcium | HEK293-Gα15 | Dong et al., 2001 |
| mMRGPRA3 | chloroquine | 27,000 | calcium | HEK293 | Liu et al., 2009 |
| rMRGPRA | chloroquine | N.D. | calcium | mDRG neurons | Liu et al., 2009 |
| adenine | 3 | cAMP inhibition | CHO | Bender et al., 2002 | |
| 60 | GTPγS | CHO | Bender et al., 2002 |
GTPγS, guanosine 5′-3-O-(thio)triphosphate; N.D., not determined; r, rat; m, mouse.