Pharmacology of MAS-related G protein–coupled receptors C
MRGPRC subfamily members are listed by the ligands to which they have been assigned. Data were generated after recombinant MRGPRC expression, despite when endogenous expression is indicated by “(e)”.
| Receptor | Ligand | EC50 | System | Reference |
|---|---|---|---|---|
| nM | ||||
| mMRGPRC | 11 | HEK293 (GFP-tag) | Han et al., 2002 | |
| γ2-MSH | 340 | HEK293 | Heo et al., 2007a | |
| 290 | HEK293 | Solinski et al., 2013 | ||
| 53 | HEK293 (GFP-tag) | Han et al., 2002 | ||
| BAM8–22 | 292 | HEK293 | Heo et al., 2007a | |
| 330 | HEK293 | Solinski et al., 2013 | ||
| Dynorphin-14 | 22 | HEK293 (GFP-tag) | Han et al., 2002 | |
| 310 | HEK293 | Solinski et al., 2013 | ||
| NPFF | 54 | HEK293 (GFP-tag) | Han et al., 2002 | |
| 358 | HEK293 | Heo et al., 2007a | ||
| NPAF | 282 | HEK293 (GFP-tag) | Han et al., 2002 | |
| SLIGRLamide | 10,000 | CHO | Liu et al., 2011 | |
| 50,000 | DRG neurons (e) | Liu et al., 2011 | ||
| rMRGPRC | γ2-MSH | 44 | HEK293-Gαqi5 | Grazzini et al., 2004 |
| 440 | HEK293 | Solinski et al., 2013 | ||
| Tyr6-γ2-MSH6–12 | 15 | HEK293-Gαqi5 | Grazzini et al., 2004 | |
| BAM8–22 | 120 | HEK293-Gαqi5 | Grazzini et al., 2004 | |
| 2600 | HEK293 | Solinski et al., 2013 |
m, mouse; r, rat.