TABLE 1

Phylogeny of MAS-related G protein–coupled receptors

All 38 MRGPR from 4 different species are listed by their designated names, aliases, and GeneID. The ascribed RefSeq records have been reviewed by National Center for Biotechnology Information (NCBI) staff and are annotated to the reference genome (mouse: annotation release 103, rat: build 5.1, human: annotation release 105, rhesus monkey: build 1.2). A straight line below the GeneID indicates that the RefSeq record has not yet been subject to individual review by NCBI staff. A GeneID in parentheses indicates that the underlying information was provided by an NCBI collaborator, an NCBI RefSeq record is yet missing, and accordingly no annotation to the reference genome exists. Notice that if MRGPRA and -B subfamily members are not numbered consecutively, numbers in between designate pseudogenes.

SubfamilyNumberAliasesGeneID
MRGPRA1MrgA1 (M)233221*
MrgA10, AdeninR, MRGPRX3 (R)252960
2a- (M)668727*
2bMrgA2 (M)235712*
3MrgA3 (M)233222*
4MrgA4 (M)235854*
5MrgA5 (M)404235*
6MrgA6 (M)381886*
7MrgA7 (M)404236*
8MrgA8 (M)(404237)*
9MrgA9 (M)668725*
10MrgA10 (M)(404243)*
11MrgA11 (M)(404244)*
12MrgA12 (M)(404245)*
13MrgA13 (M)(404246)*
14MrgA14 (M)(404247)*
15MrgA15 (M)(404248)*
16MrgA16, Gm486 (M)(404249)*
19MrgA19 (M)(404250)*
MRGPRB1MrgB1 (M, R), MRGPRX2 (R)233231*/404640
2MrgB2 (M, R), MRGPRX2-like (R)243979*/404645
3MrgB3 (M, R)404238*/(404656)†
4MrgB4 (M, R)233230*/404658
5MrgB5 (M, R)404239*/404644
6MrgB6 (R)502338
8MrgB8, MrgB13 (M, R)404240*/404643
10MrgB10, MRGPRX2 (M)243978*
11MrgB11 (M)(404251)*
13MrgB13 (M)620137*
MRGPRCMrgprc11, MRGPRX1 (M, R), MrgC11 (M), SNSR1 (R)404242*/282547
MRGPRDMrgD, TGR7 (M, R, H, Rh)211578*/293648†/
116512‡/709555§
MRGPREMrgE (M, R, H, Rh), GPR167 (H)244238*/404660†/
116534‡/706822§
MRGPRFRTA, MrgF, GPR140, GPR168 (M, R, H, Rh)211577*/266762†/
116535‡/721546§
MRGPRGMrgG (M, R, H, Rh), Gm1098 (M), GPR169 (H)381974*/49929
386746‡/721253§
MRGPRHGPR90, MrgH (M, R)80978*/404641
MRGPRX1MrgX1 (H, Rh), SNSR4 (H)259249‡/692101§
2MrgX2 (H, Rh), MrgX2-2 (Rh)117194‡/692078§
3MrgX3 (H, Rh), SNSR1 (H)117195‡/692077§
4MrgX4 (H, Rh), SNSR6 (H)117196‡/692123§
  • M, mouse; R, rat; H, human; Rh, rhesus monkey.

  • GeneIDs: *mouse; †rat; ‡human; §rhesus monkey.