Impact of β2-adrenoceptor variants on the phenotype of risk of asthma, COPD, and bronchial hyperresponsiveness
Data are an overview of candidate gene studies investigating ≥100 individuals.
| Variant | Number of Subjects | Population Origin | Variant Effect | Reference |
|---|---|---|---|---|
| c.46G>A (p.Gly16Arg) | 120 | Japanese | Gly > Arg carriers | Fukui et al. (2006) |
| 95 with severe asthma, 59 with mild asthma (92 controls) | New Zealander | Gly = Arg | Holloway et al. (2000) | |
| Gly > Arg (asthma severity) | ||||
| 201 with asthma (276 controls) | Chinese Han | Gly carriers < Arg | Qiu et al. (2010) | |
| 264 with asthma (176 controls) | African American | Gly = Arg | Tsai et al. (2006) | |
| 332 | Australian | Gly = Arg | Ramsay et al. (1999) | |
| 405 with asthma | American | Gly = Arg | Bleecker et al. (2007) | |
| 630 | British | Gly = Arg | Dewar et al. (1998) | |
| 907 | Mexican Mestizo | Gly > Arg (nocturnal asthma) | Santillan et al. (2003) | |
| 1090 | Caucasian | Gly < Arg | Matheson et al. (2006) | |
| 2250 with asthma | American | Gly = Arg | Bleecker et al. (2007) | |
| 8018 | British | Gly < Arg (+ Gln27) | Hall et al. (2006) | |
| c.79G>C (p.Gln27Glu) | 95 with severe asthma, 59 with mild asthma (92 controls) | New Zealander | Gln= Glu | Holloway et al. (2000) |
| 332 | Australian | Gln = Glu | Ramsay et al. (1999) | |
| 630 | British | Gln = Glu | Dewar et al. (1998) | |
| 907 | Mexican Mestizo | Gln < Glu | Santillan et al. (2003) | |
| 1090 | Caucasian | Gln > Glu | Matheson et al. (2006) | |
| c.[46G>A;79G>C] (p.[Gly16Arg;Gln27Glu]) | 104 children with severe asthma | American | 4-fold risk for Arg16Gly-Gln27Gln | Carroll et al. (2012) |
| 248 | Italian | Arg16Gln27 = Gly16Glu27 < Gly16Gln27 | D’amato et al. (1998) | |
| c.491C>T (p.Thr164Ile) | 630 | British | Thr = Ile | Dewar et al. (1998) |
| 8018 | British | Thr = Ile | Hall et al. (2006) | |
| 53,777 + 8971 | Danish | Thr < Ile | Thomsen et al. (2012b) |