Disease/Trait | Total Number of Studies | Hits in Adrenoceptor Genes | ||||
---|---|---|---|---|---|---|
Gene Variant | Sample Size | P Value | Reference | |||
Initial | Replicate | |||||
Asthma/COPD | 19/5 | — | ||||
Pulmonary function | 8 | — | ||||
Birth weight | 2 | ADRB1 rs1801253-G (= Gly389) | Up to 26,836 (European ancestry) | Up to 42,519 (European ancestry) | 4 × 10−9 | Horikoshi et al. (2013) |
Blood pressure/hypertension | 17 | ADRB1 rs2782980-T | 74,064 (European ancestry) | 48,607 (European ancestry) | 2 × 10−9 (MAP) | Wain et al. (2011) |
Cardiac function | 5 | — | ||||
CVD risk factors | 4 | — | ||||
Coronary (heart) disease | 28 | — | ||||
Heart failure/cardiomyopathy | 3/2 | — | ||||
Heart rate/arrhythmia | 27 | — | ||||
Glucose-related traits | 11 | ADRA2A rs10885122-G | Up to 46,186 (European descent) | Up to 76,558 (European ancestry) | 3 × 10−16 (FPG) 2 × 10−6 (HOMA-B) | Dupuis et al. (2010) |
ADRA2A rs10885122-? (interaction with BMI) | Up to 58,074 (European ancestry) | Up to 38,422 (European ancestry) | 9 ×10−8 | Manning et al. (2012) | ||
Lipid traits | 20 | — | ||||
Metabolic traits/syndrome | 5 | — | ||||
Obesity and related traits/BMI | 45 | — | ||||
Insulin-related traits | 5 | — | ||||
Diabetes | 53 | — | ||||
Platelet aggregation | 1 | ADRA2A rs869244-A | Up to 3991 (European ancestry) | Up to 840 (African American) | 3 × 10−12 (EPI) | Johnson et al. (2010) |
ADHD | 7 | — | ||||
Schizophrenia | 21 | — | ||||
Uric acid levels/gout | 4/1 | — | ||||
Gallstones | 1 | — |
ADHD, attention deficit hyperactivity disorder; BMI, body mass index; CVD, cardiovascular disease; EPI, epinephrine; FPG, fasting plasma glucose; HOMA, homeostatic model assessment; MAP, mean arterial pressure.