Drug response in dependence of α2-adrenoceptor variation: studies with healthy volunteers
| Drug | Number of Subjects | Population Origin | Variation Effect | Reference |
|---|---|---|---|---|
| Agonist-mediated vasoconstriction | ||||
| ADRA2B, c.901_909del (p.Glu301_Glu303del) | ||||
| Epinephrine | 16 | Finnish | ins > del/ins | Snapir et al. (2003a) |
| Dexmedetomidine | 16 | Finnish | ins = del (finger blood volume) | Talke et al. (2005) |
| Dexmedetomidine | 38 | African American | ins = del (dorsal hand vein) | Muszkat et al. (2005a) |
| Dexmedetomidine | 49 | American | ins = del (dorsal hand vein) | Muszkat et al. (2005b) |
| Azepexole | 50 | American | ins = del (dorsal hand vein) | King et al. (2005) |
| Antagonist-mediated inhibition of catecholamine spillover | ||||
| ADRA2C, c.964_975del (p.Glu322_Glu325del) | ||||
| Yohimbine | 29 | African American | ins > del | Neumeister et al. (2005) |
ins, insertion (indicates the wild-type variant).