Clinical impact of variations in α2-adrenoceptors
Data are an overview of candidate gene studies investigating >100 individuals.
| α2-Subtype, Variation | Number of Subjects | Population Origin | Variation Effect | Reference |
|---|---|---|---|---|
| Risk of (early onset) hypertension, blood pressure | ||||
| ADRA2B, c.901_909del (p.Glu301_Glu303del) | 109 | Italian | ins = del | Iacoviello et al. (2006) |
| 155 HT sibling pairs | American | ins = del | Baldwin et al. (1999) | |
| 173 | American | ins = del | Etzel et al. (2005) | |
| 943 HT (817 controls) | Swedish | ins < del | Von Wowern et al. (2004) | |
| 912 | Finnish | ins = del | Snapir et al. (2001) | |
| ADRA2C, c.964_975del (p.Glu322_Glu325del) | 224 healthy individuals | American | ins = del | Kurnik et al. (2007) |
| 3398 | American | ins = del | Li et al. (2006) | |
| Risk of cardiovascular event (stroke, myocardial infarction, cardiac death) | ||||
| ADRA2B, c.901_909del (p.Glu301_Glu303del) | 616 IS (512 controls) | Korean | ins < del | Oh et al. (2013) |
| 683 | Finnish | ins < del | Snapir et al. (2003b) | |
| 912 | Finnish | ins < del | Snapir et al. (2001) | |
| 1606 | Finnish | ins < del | Laukkanen et al. (2009) | |
| ADRA2C, c.964_975del (p.Glu322_Glu325del) | 345 with DCM | German | ins > del | Regitz-Zagrosek et al. (2006) |
| 601 with ACS | African American | ins = del | Cresci et al. (2012) | |
| 616 IS (512 controls) | Korean | ins = del | Oh et al. (2013) | |
| 2072 with ACS | Caucasian | ins > del | Cresci et al. (2012) | |
| Risk/onset of diabetes | ||||
| ADRA2B, c.901_909del (p.Glu301_Glu303del) | T2D, 130 with diabetic neuropathy (60 controls) | Greek | ins < del (diabetic neuropathy) | Papanas et al. (2007) |
| 199 with T2D (204 controls) | Greek | ins < del (onset) | Papazoglou et al. (2006) | |
| 506 with T2D | Finnish | ins < del | Siitonen et al. (2004) | |
| 996 with T1D | Finnish | ins < del (onset) | Heinonen et al. (2005) | |
| ins = del (progression) | ||||
| Obesity | ||||
| ADRA2B, c.901_909del (p.Glu301_Glu303del) | 909 | Greek | ins = del | Dionne et al. (2001) |
ACS, acute coronary syndrome; DCM, dilated cardiomyopathy; HT, hypertensive; ins, insertion (indicates the wild-type variant); IS, ischemic stroke; onset ins < del, onset earlier for deletion; T1D, type 1 diabetes; T2D, type 2 diabetes.