Association of the variations c.145A>G (p.Ser49Gly) and c.1165C>G (p.Arg389Gly) in the β1-adrenoceptor with heart failure
Data are an overview of candidate gene studies investigating ≥ 100 individuals.
| Variant (Cohort) | Number of Subjects | Population Origin | Variant-Dependent Effect | Reference |
|---|---|---|---|---|
| c.145A>G (p.Ser49Gly) | ||||
| Risk of HF | ||||
| DCM | 177 | Italian | Ser > Gly | Forleo et al. (2004) |
| CHF | 201 (141 controls) | Brazilian | Ser = Gly | Biolo et al. (2008) |
| DCM | 375 (492 controls) | Swedish | Ser = Gly | Magnusson et al. (2005) |
| Risk of MI | ||||
| CAD | 628 women | American | Ser = Gly | Pacanowski et al. (2008b) |
| HF-associated mortality | ||||
| DCM | 184 (77 controls) | Swedish | Ser > Gly carriers | Börjesson et al. (2000) |
| CHF | 201 | Brazilian | Ser = Gly | Biolo et al. (2008) |
| CHF | 227 | American | Ser = Gly | Shin et al. (2007) |
| DCM | 375 (492 controls) | Swedish | Ser > Gly carriers | Magnusson et al. (2005) |
| CHF | 444 | French | Ser = Gly | de Groote et al. (2005) |
| c.1165C>G (p.Arg389Gly) | ||||
| Frequency in LV tachycardia | ||||
| DCM | 163 (157 controls) | Japanese | Arg > Gly carriers | Iwai et al. (2002) |
| Exercise capacity | ||||
| ICM/DCM | 263 | American | Arg > Gly | Wagoner et al. (2002) |
| Frequency in HF/risk of HF | ||||
| DCM | 163 (157 controls) | Japanese | Arg = Gly | Iwai et al. (2002) |
| DCM | 177 | Italian | Arg = Gly | Forleo et al. (2004) |
| CHF | 201 (141 controls) | Brazilian | Arg = Gly | Biolo et al. (2008) |
| CHF | 256 (230 controls) | Italian | Arg = Gly | Covolo et al. (2004) |
| CHF | 260 (230 controls) | Italian | Arg = Gly | Metra et al. (2006) |
| DCM | 375 (492 controls) | Swedish | Arg = Gly | Magnusson et al. (2005) |
| DCM | 426 (395 controls) | French | Arg = Gly | Tesson et al. (1999) |
| Frequency in AMI/risk of MI | ||||
| AMI | 354 (354 controls) | Japanese | Arg > Gly carriers | Iwai et al. (2002) |
| CAD | 628 women | American | Arg < Gly | Pacanowski et al. (2008b) |
| HF-associated mortality | ||||
| CHF | 201 | Brazilian | Arg > Gly | Biolo et al. (2008) |
| CHF | 227 | American | Arg = Gly | Shin et al. (2007) |
| CHF | 444 | French | Arg = Gly | de Groote et al. (2005) |
| ACS | 601 | African American | Arg = Gly | Cresci et al. (2012) |
| ACS | 2072 | Caucasian | Arg = Gly | Cresci et al. (2012) |
| CAD | 2922 | American | Ser49Arg389 > Ser49Gly389/Gly49Arg389 | Pacanowski et al. (2008a) |
ACS, acute coronary syndrome; AMI, acute myocardial infarction; CAD, coronary artery disease; CHF, chronic heart failure; DCM, dilated cardiomyopathy; HF, heart failure; HT, hypertensive; ICM, idiopathic cardiomyopathy; LV, left ventricular; MI, myocardial infarction; NT, normotensive.