Impact of β2-adrenoceptor variants on heart function and failure
Data are an overview of candidate gene studies investigating ≥100 individuals.
| Variant | Number of Subjects | Population Origin | Variation Effect | Reference |
|---|---|---|---|---|
| c.46G>A (p.Gly16Arg) (+ c.79G>C (p.Gln27Glu)) | ||||
| Risk of HF, HTx, or death | ||||
| DCM | 171 | Caucasian | Gly(Glu27) > Arg(Gln27) | Forleo et al. (2004) |
| CHF | 227 | American | Gly(Glu27) < Arg(Gln27) | Shin et al. (2007) |
| CHF | 256 (230 controls) | Caucasian | Gly = Arg | Covolo et al. (2004) |
| HTx/CHF | 309/520 (328 controls) | German | Gly = Arg | Leineweber et al. (2006b) |
| 4441 white + 808 black; 155 cardiac arrest (144 controls) | American | Gly = Arg | Sotoodehnia et al. (2006) | |
| HF-associated mortality | ||||
| CHF | 259 (212 controls) | American | Gly = Arg | Liggett et al. (1998) |
| CHF | 444 | Caucasian | Gly = Arg | de Groote et al. (2005) |
| CABG | 185 | German | Gly < Arg | Frey et al. (2011) |
| ACS | 597 | American | Gly < Arg | Lanfear et al. (2005) |
| ACS | 601 | African American | Gly < Arg | Cresci et al. (2012) |
| ACS | 2072 | Caucasian | Gly = Arg | Cresci et al. (2012) |
| Risk of MI | ||||
| MI | 523 (2092 controls) | American | Arg(Gln27) = Gly(Glu27) < Gly(Gln27) | Zee et al. (2005) |
| c.79G>C (p.Gln27Glu) | ||||
| Risk of HF, HTx, or death | ||||
| CHF | 256 (230 controls) | Caucasian | Gln = Glu | Covolo et al. (2004) |
| HTx/CHF | 309/520 (328 controls) | German | Gln = Glu | Leineweber et al. (2006b) |
| HF-associated mortality | ||||
| CHF | 259 (212 controls) | American | Gln = Glu | Liggett et al. (1998) |
| CHF | 444 | Caucasian | Gln = Glu | de Groote et al. (2005) |
| ACS | 601 | African American | Gln = Glu | Cresci et al. (2012) |
| ACS | 2072 | Caucasian | Gln = Glu | Cresci et al. (2012) |
| 4441 white + 808 black, 155 cardiac arrest (144 controls) | American | Gln > Glu | Sotoodehnia et al. (2006) | |
| c.491C>T (p.Thr164Ile) | ||||
| Risk of HF, HTx, or death | ||||
| DCM | 171 | Caucasian | Thr = Ile | Forleo et al. (2004) |
| HTx/CHF | 309/520 (328 controls) | German | Thr = Ile | Leineweber et al. (2006b) |
| HF-associated mortality | ||||
| CHF | 259 (212 controls) | American | Thr < Ile | Liggett et al. (1998) |
| CHF | 444 | Caucasian | Thr = Ile | de Groote et al. (2005) |
ACS, acute coronary syndrome; CABG, coronary artery bypass graft; CHF, coronary heart disease; DCM, dilated cardiomyopathy; HTx, heart transplantation; MI, myocardial infarction.