TABLE 10

Association of the variations c.145A>G (p.Ser49Gly) and c.1165C>G (p.Arg389Gly) in the β₁-adrenoceptor with risk for hypertension, elevated heart rate, and systolic/diastolic blood pressure

Data are an overview of candidate gene studies investigating ≥100 individuals.

Variant (Cohort)	Number of Subjects	Population Origin	Variation-Dependent Effect	Reference
c.145A>G (p.Ser49Gly)
HT	101	Swedish	Ser = Gly	Karlsson et al. (2004)
Sibling pairs	102	Finnish	Ser = Gly	Bengtsson et al. (2001a)
HT	117	American	Ser = Gly	Humma et al. (2001)
Twin pairs	145	European American	Ser > Gly carriers	McCaffery et al. (2002)
HT	223	Chinese	Ser = Gly	Liu et al. (2006)
HT/NT	292/265	Swedish	Ser = Gly	Bengtsson et al. (2001a)
HT/NT	526/192	Italian	Ser = Gly	Filigheddu et al. (2004)
	890	Finnish	Ser ≥ Gly carriers	Nieminen et al. (2006)
CAD	935	Belgian	Ser = Gly	Defoor et al. (2006)
HT/NT	989/389	Japanese/Chinese	Ser carriers > Gly	Ranade et al. (2002)
c.1165C>G (p.Arg389Gly)
HT	101	Swedish	Arg = Gly	Karlsson et al. (2004)
Sibling pairs	102	Finnish	Arg > Gly carriers	Bengtsson et al. (2001a)
HT	117	American	Arg > Gly carriers	Humma et al. (2001)
Twin pairs	145	European American	Arg < Gly carriers	McCaffery et al. (2002)
HT	147	English	Arg = Gly	O’Shaughnessy et al. (2000)
HT	223	Chinese	Arg = Gly	Liu et al. (2006)
HT/NT	292/265	Swedish	Arg > Gly carriers	Bengtsson et al. (2001a)
HT/NT	526/192	Italian	Arg = Gly	Filigheddu et al. (2004)
HT/NT	775/1105	Japanese	Arg carriers > Gly	Shioji et al. (2004)
	890	Finnish	Arg = Gly	Nieminen et al. (2006)
CAD	935	Belgian	Arg carriers > Gly	Defoor et al. (2006)
HT/NT	989/389	Japanese/Chinese	Arg = Gly	Ranade et al. (2002)
	1881	White, Belgian	Arg > Gly carriers	Tikhonoff et al. (2008)
	7677	Danish Caucasian	Arg > Gly carriers	Gjesing et al. (2007)
	86,588	European	Arg > Gly	Johnson et al. (2011)

CAD, coronary artery disease; HT, hypertensive; NT, normotensive.