Phytochemicals that modify NF-κB signaling

PhytochemicalTarget Tissue/CellsEffectsInvolved Molecular MechanismReference
CapsaicinAdipose tissues macrophages of obese miceSuppress the inflammatory responsesNF-κB inactivationKang et al. (2007)
ResveratrolAdipose tissue of Zucker (fa/fa) ratsBody fat reduction and anti-inflammatory activityReduced NF-κB and inflammatory responsesGómez -Zorita et al. (2013)
Murine RAW 264.7 macrophages and microglial BV-2 cellsInhibit microglial activationSuppressed NF-κB signalingCapiralla et al. (2012)
CurcuminAGE-treated rabbit chondrocytesBlock inflammation by inhibition of I-κBα phosphorylationInhibition of NF-κB activationYang et al. (2013)
Human articular chondrocytesReduce inflammatory responsesSuppressed NF-κB activationShakibaei et al. (2007)
T cellAnti-inflammatory and immunosuppressive functionSuppressed NF-κB activationKliem et al. (2012)
MSC-like progenitor cellsFacilitate chondrogenesis of MSC-like progenitor cellsSuppressed NF-κB activationBuhrmann et al. (2010)
SilibininSKH-1 hairless miceProtect UVB-induced inflammation and photocarcinogenesisDecreased phosphorylation of p65 subunitGu et al. (2007)
CurcuminHuman pancreatic carcinoma cellsInhibit pancreatic carcinoma growth and tumor angiogenesisDecreased NF-κB activityLi et al. (2005a)
Breast cancer cellsDownregulate the expression of tumor markersDecreased NF-κBRoyt et al. (2011)
Human pancreatic carcinoma cells and murine xenograft modelsSuppress pancreatic carcinoma growth and tumor angiogenesisDownregulation of NF-κBLi et al. (2004)
Genistein253J B-V human bladder cancer cells and orthotopic tumor modelInhibit cell proliferation and induce apoptosisDownregulation of NF-κBSingh et al. (2006)
QuercetinHuman cervical cancer (HeLa) cellsInduce G2/M phase cell cycle arrest and mitochondrial apoptosisNF-κB inhibitionVidya Priyadarsini et al. (2010)
EGCGT24 human bladder cancer cellsSuppress invasion and metastasisInactivation of NF-κBQin et al. (2012)
MolluginHuman oral squamous cell carcinoma cellsInduce apoptotic cell deathSuppressed activation of NF-κBLee et al. (2013)
ResveratrolHepatocellular carcinomaInhibit tumor growth and angiogenesisSuppression of the activation of NF-κBYu et al. (2010a)
Anthocyanin-rich açaiBV-2 mouse microglial cellsMitigate LPS-induced oxidative stress and inflammationSuppression of NF-κBPoulose et al. (2012)
ResveratrolC6 astroglial cells and primary cultured cortical astrocyteModulate inflammatory stress by ammonia-induced neurotoxicityDecreased ERK and NF-κB signalingBobermin et al. (2012)
LuteolinBV-2 mouse microglial cellsInhibit LPS-induced neuroinflammationBlocked NF-κB activation and inflammatory moleculesZhu et al. (2011)
KaempferolTransient focal stroke rat modelPrevent ischemic brain injury and neuroinflammationInhibition of STAT3 and NF-κB activationYu et al. (2013)
NaringeninRat model of focal cerebral ischemia/reperfusion injuryElevate the endogenous antioxidant level and inhibit the activation of glial cellsInhibition of NF-κB activationRaza et al. (2013)
Mangiferin and morinPrimary cultured cortical neuronsReduce excitotoxic-induced neuronal cell deathInhibited the nuclear translocation of NF-κBCampos-Esparza et al. (2009)
SilymarinMesencephalic mixed neuron-glia culturesReduce microglial activation and inflammatory mediators by LPSInhibition of NF-κB activationWang et al. (2002)
Soybean isoflavoneAβ-injected rat brainImprove spatial learning and memoryInhibited TLR4 and NF-κBDing et al. (2011)
EGCGAβ-injected mice brainPrevent loss of learning and memory and apoptotic neuronal cell deathInhibited ERK and NF-κB activationLee et al. (2009)
Autoimmune encephalomyelitis mice modelReduce neuroinflammation and neuronal cell damageIntracellular accumulation of IκBα and inhibition of NF-κB activationAktas et al. (2004)
WogoninBV-2 mouse microglial cellsInhibit inflammatory activationDecreased NF-κB activationLee et al. (2003)
Caffeic acidPrimary cultured rat cerebellar granule neuronsDecrease apoptotic cell deathBlocked NF-κB and caspase activityAmodio et al. (2003)
  • AGE, advanced glycation end product; MSC, mesenchymal stem cell; STAT3, signal transducer and activator of transcription 3; TLR4, Toll-like receptor 4.