Agonist profiles of mammalian P2X7
| Species | Sequence Identity | EC50 | References | ||
|---|---|---|---|---|---|
| ATP | BzATP | ATPγS | |||
| % | µM | ||||
| Human | 100 | 96 | 5 | >100 | Bianchi et al., 1999 |
| Rhesus macaque | 96 | 800 | 58 | N.D. | Bradley et al., 2011b |
| Dog | 85 | 1148 | 21 | N.D. | Roman et al., 2009 |
| Rat | 80 | 85 | 4 | >1000 | Surprenant et al., 1996 |
| Mouse (BALB/c) | 80 | 200 | 60 | >1000 | Donnelly-Roberts et al., 2009 |
| Mouse (C57BL/6) | 80 | 162 | 36 | >1000 | Donnelly-Roberts et al., 2009 |
| Guinea pig | 77 | 603 | >200 | N.D. | Fonfria et al., 2008 |
N.D., not determined.