Phytochemical | Target Tissue/Cells | Effects | Involved Molecular Mechanism | Reference |
---|---|---|---|---|
EGCG | Nonsmall cell lung cancer cells and A549 xenografted tumors of nude mice | Inhibit angiogenesis | Inhibition of HIF-1α | He et al. (2013) |
Human pancreatic carcinoma cells | Inhibit cell proliferation | Inhibition of HIF-1α | Zhu et al. (2012) | |
Rat kidney | Block iron uptake | Prevented HIF-1α hydroxylation by prolyl hydroxylase inhibition | Manalo et al. (2011) | |
3,3′-diindolylmethane | Hypoxic tumor cells | Interact mitochondrialF1 F0-ATPase and increased ROS and O2 | Reduced HIF-1α | Riby et al. (2008) |
Ferulic acid | HUVECs | Augment angiogenesis | Upregulation of HIF-1α | Lin et al. (2010) |
Honokiol | HUVECs | Promote angiogenesis | Inhibition of HIF pathway | Vavilala et al. (2012) |
Luteolin | Human retinal microvascular endothelial cells | Inhibit retinal neovascularization | Suppressed HIF-1α expression | Park et al. (2012b) |
Naringenin and quercetin | Hypoxia-induced mice model | Ameliorate hypoxia-induced brain dysfunction | Decreased HIF-1α | Sarkar et al. (2012) |
Salvia miltiorrhiza | Human gastric cancer cells and human hepatocarcinoma cells | Anticancer activity | Suppressed HIF-1α accumulation | Dat et al. (2007) |
Silibinin | SKH1 hairless mice | Prevent UVB-induced photocarcinogenesis | Decreased HIF-1α | Gu et al. (2007) |
Ischemic stroke model | Reduce infarct volume and brain edema | Upregulation of HIF-1α | Wang et al. (2012a) | |
Soy-containing diets | Acute stroke in female rats | Decrease the expression of apoptotic mediator | Inhibition of HIF-1α activity | Ma et al. (2013) |
Quercetin | Human breast cancer cells | Inhibit cell proliferation and invasion | Suppressed the expression of HIF-1α | Li et al. (2013b) |
Gastric cancer cells | Induce apoptotic cell death | Modulation of HIF-1α | Wang et al. (2011b) | |
Wogonin | Acute UVB-irradiated hairless mice | Reduce skin damage | Inhibition of HIF-1α | Kimura and Sumiyoshi (2011) |
HUVEC, human umbilical vein endothelial cell.