TABLE 2

Effects of monoamine uptake inhibitors on intracranial self-stimulation

Drug Pharmacology^a		Doses	Route	Strain/Species	Sex	ICSS Procedure^b		Drug Effect^c	Dependent Measure	Reference
Drug Name	Selectivity	Doses	Route	Strain/Species	Sex	Structure	Parameter	Drug Effect^c	Dependent Measure	Reference
		mg/kg
Cocaine	DA/NE/5HT	0.63–10	s.c.	Wistar rat	Male	Free operant		Facilitation	↑rate	Wauquier and Niemergeers, 1974
Cocaine	DA/NE/5HT	1–10	i.p.	Fischer rat	Male	Discrete trial	Amplitude	Facilitation	↓CIT	Esposito et al., 1978
Cocaine	DA/NE/5HT	1–10	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Facilitation	↑rate	Negus et al., 2012a
Cocaine	DA/NE/5HT	1.25–10	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Facilitation	↓θ₀	Tomasiewicz et al., 2008
Cocaine	DA/NE/5HT	1–30	i.p.	C57Bl6/J mouse	Male	Hybrid	Frequency	Facilitation	↓θ₀	Fish et al., 2010
Cocaine	DA/NE/5HT	1–30	i.p.	DBA mouse	Male	Hybrid	Frequency	Facilitation	↓θ₀	Fish et al., 2010
MDPV	DA/NE>5HT	0.32–3.2	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Facilitation	↑rate	Bonano et al., 2014
MDPV	DA/NE>5HT	0.1–2.0	i.p.	Sprague-Dawley rat	Male	Discrete trial	Amplitude	Facilitation	↓CIT	Watterson et al., 2014
GBR 12935	DA>NE/5HT	1.0–10	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Facilitation	↑rate	K. Freitas and S. S. Negus, unpublished
RTI-113	DA>NE/5HT	0.32–3.2	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Facilitation	↑rate	Rosenberg et al., 2013
Methylphenidate	DA/NE>5HT	0.1–10	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Facilitation	↑rate	K. Freitas and S. S. Negus, unpublished
Buproprion	DA/NE>5HT	3.2–32	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Facilitation	↑rate	Rosenberg et al., 2013
RTI-112	DA/NE/5HT	0.1–1.0	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Facilitation	↑rate	Rosenberg et al., 2013
Amitifadine	DA/NE/5HT	1–10	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Mixed	↑↓rate	L. L. Miller and S. S. Negus, unpublished
Citalopram	DA/NE<5HT	3.2–32	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Depression	↓rate	Rosenberg et al., 2013
Clomipramine	DA<NE/5HT	3.2–32	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Depression	↓rate	Rosenberg et al., 2013
Fluoxetine	DA/NE<5HT	1.0–10	i.p.	Sprague-Dawley rat	Male	Free operant		Depression	↓rate	Katz and Carroll, 1977
Fluoxetine	DA/NE<5HT	2.5-20	i.p.	Wistar rat	Male	Discrete trial	Amplitude	Depression	↑CIT	Lee and Kornetsky, 1998
Nisoxetine	DA/5HT<NE	1–10	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Depression	↓rate	Rosenberg et al., 2013
Nortryptaline	DA<5HT<NE	1–10	i.p.	Sprague-Dawley rat	Male	Hybrid	Frequency	Depression	↓rate	Rosenberg et al., 2013

Rate, response rate; CIT, current-intensity threshold; θ₀, theta-0 threshold.
↵^a Selectivity for monoamine uptake inhibition.
↵^b First column indicates structure of experimental session (see text for details). Second column indicates stimulation parameter under manipulation across trials.
↵^c Most prominent drug effect on ICSS.