Effect of most common medications of cardiovascular risk factors on ischemia/reperfusion (I/R) injury as well as pre-, post-, and remote conditioning in the majority of the studies
It should be noted that very few data are available so far on the effect of medications on conditioning strategies.
| Medication | I/R Injury | Preconditioning | Postconditioning | Remote Conditioning |
|---|---|---|---|---|
| Nitrate tolerance | ↑ | ↓ | ↓ | N.D. |
| Statins | ↓ | ↓ | ↓ | N.D. |
| Antidiabetics | ||||
| KATP inhibitors | ↑ | ↓ | ↓ | ↓ |
| Others | ↓ | — | — | N.D. |
| β-Blockers | ↓ | ↓— | — | N.D. |
| ACE inhibitors | ↓ | ↑ | N.D. | N.D. |
| AT1 antagonists | ↓ | ↑ | N.D. | N.D. |
| Calcium channel blockers | ↓— | — | N.D. | N.D. |
| COX inhibitors | ↑ | N.D. | N.D. | N.D. |
N.D., no data available; ↑, enhance, ↓, attenuate, —, no effect.