TABLE 3

ASIC protein interaction partners

Interaction PartnerASIC Subtypes ConcernedSite of interaction on ASIC (C or N Terminus)aConsequencesSystemReferences
A kinase-anchoring protein (AKAP) 79/150 and calcineurin1a, 2aASIC2a: N & C, ASIC1a: CAKAP 150 binding increases ASIC currents; calcineurin decreases ASIC currents.Transfected cortical neurons or CHO cellsChai et al., 2007
Channel-interacting PDZ domain protein (CIPP)3C, PDZEnhances peak current amplitude of ASIC3Transfected COS cellsAnzai et al., 2002
PICK11a, 2a, 2bC, PDZAffects localization of ASIC1a and allows ASIC2a current increase by PKC.Mainly recombinant expression systemsBaron et al., 2002; Duggan et al., 2002; Hruska-Hageman et al., 2002; Deval et al., 2004
Allows current increase of ASIC2b/3 channels by PICK1-dependent PKC phosphorylation of ASIC3.
Lin7B3C, PDZIncreases ASIC3 cell surface expression and current amplitudeTransfected CHO cellsHruska-Hageman et al., 2004
MAGI-1b (membrane-associated guanylate kinase)3C, PDZbIncreases ASIC3 current amplitudeTransfected CHO cellsHruska-Hageman et al., 2004
PIST3C, PDZbIncreases ASIC3 current amplitudeTransfected CHO cellsHruska-Hageman et al., 2004
PSD953CReduces ASIC3 cell surface expression and current amplitudeTransfected CHO cellsHruska-Hageman et al., 2004; Eshcol et al., 2008; Zha et al., 2009
Stomatin1, 2, 3NRInhibits ASIC3 current amplitude and accelerates ASIC2a desensitizationPrice et al., 2004
Stomatin-like proteins (STOML)1, 2, 3NRASIC- and STOML-subtype–dependent, inhibition of current amplitude and acceleration of desensitizationTransfected cells, neuronsLapatsina et al., 2012; Kozlenkov et al., 2014
Na+/H+ exchanger regulatory factor (NHERF)3C, PDZbIncreases ASIC current amplitudeVarious cell linesDeval et al., 2006
Annexin II light chain p11.11aNIncreases cell surface expression and current amplitudeDRG neurons and transfected cellsDonier et al., 2005
α-Actinin1aCEffect on ASIC1a current amplitude and properties, depending on actinin subtypeCell lines and neuronsSchnizler et al., 2009
High-conductance Ca2+- and voltage-activated K+ (BK) channel1aNRReciprocal current inhibitionTransfected cells and neuronsPetroff et al., 2008, 2012
P2X channels3NRATP sensitizes ASIC3 for activation by protonsNeurons and transfected cellsBirdsong et al., 2010

  • NR, not resolved

  • ↵a “PDZ” in this column indicates that the interacting protein binds to the ASIC PDZ binding domain.

  • ↵b ASIC3 PDZ binding domain is different from that of ASIC1 and ASIC2. These proteins did not bind to ASIC1 or ASIC2.