Nociceptive, inflammatory, and pruritic pathways caused by receptor-mediated TRP channel stimulation
| Receptor Signaling-Mediated Activation | |||
|---|---|---|---|
| Receptor (Ligand) | Signaling Mechanism | Reference | |
| TRPV1 | B1, B2 (bradykinin) | PKC, 12-LOX | Cesare and McNaughton, 1996; Vellani et al., 2001; Shin et al., 2002; Katanosaka et al., 2008 |
| H1R, H2R (histamine) | PLA2/ 12-LOX, PLC/PKC | Kim et al., 2004; Shim et al., 2007; Imamachi et al., 2009; Kajihara et al., 2010 | |
| PAR2 (trypsin, PAR2-activating peptide) | PLC, PKA, PKC, PKD | Dai et al., 2004; Amadesi et al., 2006, 2009; Vellani et al., 2010 | |
| NPR-C (natriuretic peptide C) | βγ G proteins/ PLCβ/PKC | Loo et al., 2012 | |
| Prokineticin PK1, PK2 (Bv8) | PKC | Negri et al., 2006; Vellani et al., 2006 | |
| TrkA (NGF) | PKC, PI3K, p38, B2 | Ji et al., 2002; Lee et al., 2002b; Bonnington and McNaughton, 2003; Stein et al., 2006 | |
| μ-Opioid receptor (morphine, DAMGO) | β-Arrestin | Zhang et al., 2005; Forster et al., 2009; Rowan et al., 2014 | |
| MrgA3 (chloroquine) | PLCβ, PKC | Than et al., 2013 | |
| EP1 EP2, & EP4 (PGE2) | PKC, PKA, and AKAP | Gu et al., 2003; Moriyama et al., 2005; Zhang et al., 2008 | |
| IP receptor (PGI2) | PKA | Moriyama et al., 2005 | |
| 5-HT receptor (5-HT2, 5-HT4, 5-HT7) | PKC, PKA, and AKAP | Sugiuar et al., 2004; Ohta et al., 2006 | |
| Signaling with unknown receptor or intermediates | |||
| Prolactin receptor (prolactin/estradiol) | — | Diogenes et al., 2006; Patil et al., 2013 | |
| TrkA (NGF), Ret/GFRα (GDNF), Mrg receptor | — | Luo et al., 2007; Ciobanu et al., 2009 | |
| TRPV2 | FcεRI (IgE) | Acyl CoA/PKA | Stokes et al., 2004 |
| Signaling with unknown receptor or intermediates | |||
| — | Lysophospholipids/ Gαq/ PI3K | Monet et al., 2009 | |
| TRPV3 | H1R (histamine) | Gq/11, PLCβ | Xu et al., 2006 |
| B2 (bradykinin) | PKC | Hu et al., 2004 | |
| Muscarinic M1 (carbachol) | PLC | Xu et al., 2006; Doerner et al., 2011 | |
| TRPV4 | B2 (Bradykinin) | PLC, PKC | Fan et al., 2009 |
| PAR2 (proteases) | PLC, PLA2, PKA, PKC, PKD, MAPK, and 5′,6′-EET | Grant et al., 2007; Cenac et al., 2008; Sipe et al., 2008; Li et al., 2011; Poole et al., 2013 | |
| 5-HT receptor | PLC, PLA2, PKC, and MAPK | Cenac et al., 2010 | |
| Signaling with unknown receptor or intermediates | |||
| H1R (histamine) | — | Cenac et al., 2010 | |
| Muscarinic M1 (carbachol) | — | Sonkusare et al., 2012 | |
| Src Kinase | Wegierski et al., 2009; Poole et al., 2013 | ||
| PGE2 | Alessandri-Haber et al., 2003 | ||
| TRPM3 | Muscarinic M1 (Carbachol) | — | Lee et al., 2003 |
| TRPM8 | EP1 (PGE2) | PKA | Linte et al., 2007 |
| 5-HT1B (sumatriptan, CP 94253) | Phospholipase D1, PIP5-kinase | Vinuela-Fernandez et al., 2014 | |
| Signaling with unknown receptor or intermediates | |||
| TrkA (NGF) Ret/GFRα (GDNF, artemin), Mrgpr | — | Luo et al., 2007; Ciobanu et al., 2009; Lippoldt et al., 2013 | |
| Prolactin receptor (prolactin/estradiol) | — | Patil et al., 2013 | |
| PLA2 | Gentry et al., 2010 | ||
| Gαq (inhibition) | Zhang et al., 2012 | ||
| TRPA1 | B2 (bradykinin) | PLC/PKA/TRPV1 Ca2+ flux | Bautista et al., 2006; Katanosaka et al., 2008; Wang et al., 2008; Schmidt et al., 2009 |
| H1R (histamine) | Mrgpr signaling | Wilson et al., 2011 | |
| PAR2 (proteases) | PLC | Bautista et al., 2005; Dai et al., 2007; Cattaruzza et al., 2010 | |
| MrgC11 (Bam8-22) | PLC, PKC | Wilson et al., 2011 | |
| MrgA3 (chloroquine) | βγ G proteins | Wilson et al., 2011; Than et al., 2013 | |
| Signaling with unknown receptor or intermediates | |||
| TrkA (NGF) Ret/GFRα (GDNF), Mrg receptor | — | Diogenes et al., 2007; Luo et al., 2007; Ciobanu et al., 2009 | |
| Prolactin receptor (prolactin/estradiol) | — | Patil et al., 2013 | |
| μ-Opioid receptor (morphine) | — | Forster et al., 2009 | |
PI3K, phosphoinositide 3-kinase; PKD, protein kinase D.