Modulators of PLD activity
| Protein Name | Isoform | Mechanism | Interaction Site | References |
|---|---|---|---|---|
| Activators | ||||
| PKC α,β1,β2 | PLD1 | Protein–protein interaction | N-terminal (AAs 50–115), C-terminal (AAs 325–582) | Conricode et al. (1992, 1994), Ohguchi et al. (1996), Hammond et al. (1997), Lee et al. (1997b), Min et al. (1998), Park et al. (1998), Sung et al. (1999b), Zhang et al. (1999), Siddiqi et al. (2000) |
| Arf | PLD1 | Protein–protein interaction | Unknown | Brown et al. (1993), Cockcroft et al. (1994), Hammond et al. (1997), Lopez et al. (1998), Min et al. (1998) |
| RhoA family | PLD1 | Protein–protein interaction | C-terminal (K946A, V950A, R955A, K962A) | Olson et al. (1991), Bowman et al. (1993), Kwak et al. (1995), Malcolm et al. (1994), Brown et al. (1995), Siddiqi et al. (1995), Singer et al. (1996), Hammond et al. (1997), Sung et al. (1997), Yamazaki et al. (1999), Cai and Exton (2001) |
| PKN | PLD1 | Protein–protein interaction | AAs 228–598 | Oishi et al. (2001) |
| Rheb | PLD1 | Protein–protein interaction | Unknown | Sun et al. (2008) |
| Ras | PLD1 | Indirect protein–protein interaction | Unknown | Jiang et al. (1995a) |
| RaIA | PLD1 | Indirect protein–protein interaction | Unknown | Jiang et al. (1995b), Kim and Wong (1998) |
| Cofilin | PLD1 | Protein–protein interaction | Region between loop and CRIII | Han et al. (2007) |
| CtBP1/BARS | PLD1 | Protein–protein interaction | Unknown | Haga et al. (2009) |
| AMPK | PLD1 | Phosphorylation | S505 | Kim et al. (2010) |
| p90 RSK | PLD1 | Phosphorylation | T147 | Zeniou-Meyer et al. (2008) |
| Cdk5 | PLD2 | Phosphorylation | S134 | Lee et al. (2008) |
| Grb2 | PLD2 | Protein–protein interaction | Y169/Y179 | Di Fulvio et al. (2006) |
| PKCδ | PLD2 | Phosphorylation | S566 | Han et al. (2002a), Chae et al. (2010) |
| Inhibitors | ||||
| AP3 | PLD1 | Protein–protein interaction | Unknown | Lee et al. (1997a) |
| Aldolase | PLD2 | Protein–protein interaction | PH domain | Kim et al. (2002) |
| α-Actinin | PLD2 | Protein–protein interaction | Unknown | Park et al. (2000) |
| CRMP-2 | PLD2 | Protein–protein interaction | N terminus | Lee et al. (2002) |
| Munc-18-1 | PLD1/PLD2 | Protein–protein interaction | PX domains | Lee et al. (2004) |
| Amphiphysin I and II | PLD1/PLD2 | Protein–protein interaction | Unknown | Lee et al. (2000) |
| F-actin | PLD1/PLD2 | Protein–protein interaction | Region between CRIII and CRIV | Lee et al. (2001), Kusner et al. (2002) |
| PKCα | PLD1/PLD2 | Phosphorylation | PLD1 (S2, T147, S561), PLD2 (S134, S146, S243, T72, T99, T100, T252) | Kim et al. (1999a), Chen and Exton (2005) |
AA, amino acid; BARS, brefeldin A ADP-ribosylated substrate; RSK, ribosomal S6 kinase.