Properties of PTHR1 and PTHR2
| PTHR1 | PTHR2 | |
|---|---|---|
| Ligand | PTH, PTHrP | TIP39 |
| Identity (%) | 100 | 51 |
| Role | Ca homeostasis (PTH); bone/tissue development (PTHrP) | Nociception, spermatogenesis |
| Tissue expression | Bone osteoblasts, renal proximal and distal tubule cells, tissue primordia (e.g., growth plate chondrocytes) | Brain, vasculature, testis |
| Signaling | cAMP/PKA; PLC/IP3/Ca/PKC; ERK1/2 | cAMP/PKA; PLC/IP3/Ca/PKC |
| Species | All vertebrates | Vertebrates, excluding birds |