TABLE 4

Peptide ligands for galanin receptors with type of in vivo activity

Peptide Ligands	Sequence	Receptor Specificity	Activity	Species
Human galanin (1–30)	GWTLNSAGYLLGPHAVGNHRSFSDKNGLTS	none	agonist
Rat galanin (1–29)	GWTLNSAGYLLGPHAIDNHRSFSDKHGLT	none	agonist
Porcine galanin (1–29)	GWTLNSAGYLLGPHAIDNHRSFHDKYGLA	none	agonist
Galanin (2–11) (AR-M1896)	WTLNSAGYLL	GAL₂/GAL₃^{^a}^,^{^b}	agonist^{^a}	rat
C7 = galanin (1–13)-spantide I	GWTLNSAGYLLGPRPKPQQWFWLL	none	antagonist^{^c}	rat
M15 = galantide= galanin (1–13)-substance P (5–11) amide	GWTLNSAGYLLGPQQFFGLM	none	antagonist^{^d}	rat
M32 = galanin (1–13)-neuropeptide Y (25–36) amide	GWTLNSAGYLLGPRHYINLITRQRY	none	antagonist^{^e}	rat
M35 = galanin(1–13)-bradykinin(2–9) amide	GWTLNSAGYLLGPPPGFSPFR	none	antagonist^{^f}	rat
M40 = Galanin (1–13)-Pro-Pro-(Ala-Leu-)₂Ala amide	GWTLNSAGYLLGPALALA	none	antagonist^{^c}^,^{^g}	rat
M617 = galanin(1–13)-Gln14-bradykinin(2–9) amide	GWTLNSAGYLLGPQPGFSPFR	GAL₁>GAL₂	agonist^{^h}^,^ⁱ	rat
M871 = galanin (2–13)-Glu-His-(Pro)₃(Ala-Leu)₂Ala amide	WTLNSAGYLLGPEHPPPALALA	GAL₂^{^j}^,^{^k}	antagonist^ⁱ	rat
M1160	RGRGNWLNSAGYLLGPVLPPPALALA	GAL₂^{^l}	agonist^{^l}	mouse
J18	RGRGNWTLNSAGYLLGPkkK(eNH_C(O)_stearic _acid)k	GAL₂>GAL₃>GAL₁	agonist^{^m}	mouse
Gal-B2 (NAX 5055)	(Sar)WTLNSAGYLLGPKKK_palmitoylK	GAL₁>GAL₂^ⁿ	agonist^{^o}	mouse
[N-Me, des-Sar]Gal-B2	_N-MeWTLNSAGYLLGPKKK_palmitoylK	GAL₂>GAL₁^ⁿ	agonist^{^p}	mouse
Gal-S2	(Sar)WTLNSAGYLLGPXKKKX	none^ⁿ	Agonist^{^q}	mouse
Human galanin-like peptide GALP (1–60)	APAHRGRGGWTLNSAGYLLGPVLHLPQMGDQDGKRETALEILDLWKAIDGLPYSHPPQPS	none^{^r}	agonist^{^s}	mouse
Human GALP (3–32)	AHRGRGGWTLNSAGYLLGPVLHLPQMGDQ	none^{^r}^,^ⁿ	agonist^{^s}	mouse

↵^a Liu et al. (2001).
↵^b Lu et al. (2005b).
↵^c Crawley et al. (1993).
↵^d Bartfai et al. (1991).
↵^e Xu et al. (1995a).
↵^f Wiesenfeld-Hallin et al. (1992).
↵^g Leibowitz and Kim (1992).
↵^h Lundström et al. (2005b).
↵ⁱ Jimenez-Andrade et al. (2006).
↵^j Sollenberg et al. (2006).
↵^k Sollenberg et al. (2010).
↵^l Saar et al. (2013b).
↵^m Saar et al. (2013b).
↵ⁿ Not tested for GAL₃; X = (S)-2-(4-pentenyl)alanine.
↵^o Bulaj et al. (2008).
↵^p Robertson et al. (2010).
↵^q Green et al. (2013).
↵^r Lang et al. (2005).
↵^s Schmidhuber et al. (2007).