Action | Ligand | Psychomotor Stimulant | Stimulus Effects of Cocaine | Impulsive Action | Cocaine Self-Administration | ||
---|---|---|---|---|---|---|---|
Reward | Cocaine-Seeking | ||||||
Cue | Cocaine | ||||||
5-HT2AR agonist | DOIa | ↑/NE | Partial | ↑ | NP | NP | NP |
5-HT2AR antagonist | MDL 100907,b SR 463491Bc | ↓ | ↓ | ↓ | ↓NE | ↓ | ↓ |
5-HT2CR agonist | MK 212,d Ro 60-0175,e WAY 163909,f WAY 161503g | ↓ | ↓ | ↓ | ↓ | ↓ | ↓ |
5-HT2CR antagonisth | SB242084,i RS102221j | ↑ | ↑ | ↑ | ↑ | NE | ↑ |
NE, no effect was observed under the treatment conditions employed; NP, no publications identified for these manipulations.
↵a Evenden, 1998; Evenden and Ryan, 1999; Koskinen et al., 2000; Filip et al., 2004; Blokland et al., 2005.
↵b McMahon and Cunningham, 2001; Fantegrossi et al., 2002; Fletcher et al., 2002, 2011; Winstanely et al., 2003, 2004; Fletcher, 2007; Nic Dhonnchadha et al., 2009; Anastasio et al., 2011; Pockros et al., 2011.
↵c Filip et al., 2004, 2006; Filip, 2005.
↵d Callahan and Cunningham, 1995; Filip and Cunningham, 2003; Filip et al., 2004; Neisewander and Acosta, 2007.
↵e Burbassi and Cervo, 2008; Fletcher et al., 2008, 2011; Grottick et al., 2000; Manvich et al., 2012a.
↵f Navarra et al., 2008; Cunningham et al., 2011, 2013; Anastasio et al., 2014a.
↵g Katsidoni et al., 2011.
↵h SB242084 alone supported self-administration in squirrel monkeys (Manvich et al., 2012b).
↵i Fletcher et al., 2002, 2006, 2008; Winstanely et al., 2003; Frankel and Cunningham, 2004; Neisewander and Acosta, 2007; Burbassi and Cervo, 2008; Manvich et al., 2012b; Pennanen et al., 2013.
↵j Filip and Cunningham, 2003.