Ligand | Binding Affinity pKi, pKD | cAMP pEC50 | GTPγS pEC50 | Reference | |
---|---|---|---|---|---|
hINSL5 | AG | 7.33 | 8.51 | Shabanpoor et al. (2012) | |
hINSL5 | AG | 7.59 | 8.62 | Belgi et al. (2013) | |
hINSL5 | AG | 8.66 | 8.94 | Zhu et al. (2008) | |
hINSL5 | AG | 8.8 | 8.92 | 8.89 | Liu et al. (2005b) |
hINSL5 amide | AG | 6.94 | 7.48 | Belgi et al. (2011) | |
mINSL5 | AG | 8.47 | 9.29 | Belgi et al. (2013) | |
mINSL5 amide | AG | 7.07 | 6.85 | Belgi et al. (2011) | |
Relaxin-3 | AG | 8.81 | 9.01 | Zhu et al. (2008) | |
Relaxin-3 | AG | 8.83 | 9.02 | Kuei et al. (2007) | |
Relaxin-3 B-chain | AG | 7.07 | 7.06 | ∼7.0 | Liu et al. (2003b) |
Relaxin-3 B-chain | AG | 6.9 | Liu et al. (2005a) | ||
R3/I5 | AG | 8.92 | 9.04 | Liu et al. (2005a) | |
R3/I5 | AG | 8.88 | 8.94 | Kuei et al. (2007) | |
Minimized hINSL5 analog 7 | PA | 6.28 | 7.40 | Belgi et al. (2013) | |
Relaxin-3 | AG | 8.94 | Shabanpoor et al. (2012) | ||
Minimized relaxin-3 analog 2 | AG | 7.1 | 7.7 | Shabanpoor et al. (2012) | |
Minimized relaxin-3 analog 3 | ANT | 6.6 | N.A. | Shabanpoor et al. (2012) | |
R3(BΔ23–27)R/I5 | ANT | ∼8 | N.D. | Haugaard-Kedstrom et al. (2011) | |
R3(BΔ23–27)R/I5 | ANT | 8.64 | N.A. | Kuei et al. (2007) | |
R3 B1–22R | N.A. | N.D. | Haugaard-Kedstrom et al. (2011) |
AG, agonist; ANT, antagonist; N.A., no activity; PA, partial agonist.