TLR2 | Heart /vasculature | Atherosclerosis | Antagonistic |
Lung | Asthma | Antagonistic |
Kidney | Ischemia/reperfusion | Antagonistic |
Pancreas | Diabetes | Antagonistic |
TLR3 | Systemic | Vaccine adjuvant | Agonistic |
Breast | Anticancer | Agonistic |
Renal system | Anticancer | Agonistic |
Eye | CNV inhibition in AMD | Agonistic |
Brain | Antiviral (WNV) | Antagonistic |
TLR4 | Heart /vasculature | Atherosclerosis | Antagonistic |
Lung | Asthma | Antagonistic |
Kidney | Ischemia/reperfusion | Antagonistic |
Pancreas | Diabetes | Antagonistic |
Joints | Rheumatoid arthritis | Antagonistic |
Brain | Alzhiemer’s disease, Parkinson's disease | Antagonistic |
Systemic | Sepsis | Antagonistic |
Vaccine adjuvant | Agonistic |
TLR5 | Hematopoietic | Radioprotective | Agonistic |
system and GI-tract | Vaccine adjuvant (influenza virus) | Agonistic |
Systemic | Treatment of Crohn’s Disease | Antagonistic |
GI-tract | | |
TLR7/8 | Skin | Treatment of viral induced lesions | Agonistic |
Blood | (caused by papilloma virus and herpes simplex virus) | Agonistic |
Systemic | Primary tumors | Agonistic |
Cutaneous metastases | Agonistic |
Antiviral (HCV) | Agonistic |
Chronic lymphocyte leukemia | Antagonistic |
SLE | |
TLR9 | Prostate | Anticancer | Agonistic |
Systemic | Vaccine adjuvant | Agonistic |
Systemic | Tumor vaccine adjuvant | Agonistic |
Lung/systemic | Asthma/allergy | Agonistic |