TABLE 1

TLR targets in different diseases

TLRTissueTherapeutic Potential/UseAction
TLR2Heart /vasculatureAtherosclerosisAntagonistic
LungAsthmaAntagonistic
KidneyIschemia/reperfusionAntagonistic
PancreasDiabetesAntagonistic
TLR3SystemicVaccine adjuvantAgonistic
BreastAnticancerAgonistic
Renal systemAnticancerAgonistic
EyeCNV inhibition in AMDAgonistic
BrainAntiviral (WNV)Antagonistic
TLR4Heart /vasculatureAtherosclerosisAntagonistic
LungAsthmaAntagonistic
KidneyIschemia/reperfusionAntagonistic
PancreasDiabetesAntagonistic
JointsRheumatoid arthritisAntagonistic
BrainAlzhiemer’s disease, Parkinson's diseaseAntagonistic
SystemicSepsisAntagonistic
Vaccine adjuvantAgonistic
TLR5HematopoieticRadioprotectiveAgonistic
system and GI-tractVaccine adjuvant (influenza virus)Agonistic
SystemicTreatment of Crohn’s DiseaseAntagonistic
GI-tract
TLR7/8SkinTreatment of viral induced lesionsAgonistic
Blood(caused by papilloma virus and herpes simplex virus)Agonistic
SystemicPrimary tumorsAgonistic
Cutaneous metastasesAgonistic
Antiviral (HCV)Agonistic
Chronic lymphocyte leukemiaAntagonistic
SLE
TLR9ProstateAnticancerAgonistic
SystemicVaccine adjuvantAgonistic
SystemicTumor vaccine adjuvantAgonistic
Lung/systemicAsthma/allergyAgonistic