TABLE 2

Gene composition of NLR subfamilies

Murine genes are shown in parentheses.

NLR SubfamilyType of Effector DomainFamily Gene Members
NLRAAcidic activation domainCIITA; (CIIta)
NLRBBaculovirus inhibitor of apoptosis repeatsNAIP; (Naip1-7)
NLRCCaspase activation and recruitment domainNOD1, NOD2, NLRC3, NLRC4, NLRC5;(Nod1, Nod2, Nlrc3, 4, 5)
NLRPPyrin domainNLRP1-14; (Nlrp1a-c, 2, 3, 4a-4g, 5, 6, 9a-c, 10, 12, 14
NLRXUnknown domainNLRX1; (Nlrx1)
  • CIITA, class II, major histocompatibility complex, transactivator.