Factors determining the drug-loading capacity of PSi
| The surface area is an essential parameter to obtaining high loading capacity/degree. |
| The ratio of the pore diameter to the peptide molecule size needs to be sufficiently high to achieve effective penetration of the molecules in the pores. |
| Hydrophobic surfaces can facilitate peptide loading in aqueous solutions but might be hazardous to peptide stability if the surface of PSi is not passivized before the peptide loading. |
| Electrostatic attraction is an effective way to promote loading of the peptides in PSi carriers. |
| The charges of the peptide and PSi particles depend on the properties of the medium (e.g., solvent, pH, and excipients), which need to be considered in planning the loading procedure. |