Examples of different peptide delivery systems
| Drug Delivery System (Route) | Peptide | Outcome | Reference |
|---|---|---|---|
| Unilamellar liposomes (inhalation) | Vasoactive intestinal peptide | Sustained release and extended pharmacologic effect ex vivo | Hajos et al., 2008 |
| Poly(lactide-co-glycolide) microspheres (i.m. ) | Vapreotide | Erosion-controlled release up to 4 wk in vivo | Blanco-Prieto et al., 2000 |
| Water in oil microemulsion (intranasal) | Insulin | Relative bioavailability 21.5% to s.c. administration | Sintov et al., 2010 |
| Solid lipid nanoparticle flocculates (pulmonary) | Insulin | Relative bioavailability 35.6% to s.c. administration | Yang et al., 2012a |