Target | Modification | Transgene/Mouse | Phenotype | Reference |
---|---|---|---|---|
Rock1 | ||||
BP/endothelial function/hypertension | Rock1+/− | Normal basal BP | Rikitake et al., 2005 | |
Experimental hypertension similar to control mice | ||||
Reduced basal systolic BP | Yao et al., 2013 | |||
Increased NO production and endothelial-dependent relaxation | ||||
Abolition of diabetes-induced rise in BP and endothelial dysfunction | ||||
Atherosclerosis | Bone marrow Rock1−/− | Transplanted in Ldlr−/− mice | Reduced atherosclerosis | Wang et al., 2008 |
Reduced lipid accumulation | ||||
Reduced macrophage lipid uptake | ||||
Neointimal thickening | Rock1+/− | Reduced neointimal formation after vascular injury | Noma et al., 2008 | |
Bone marrow Rock1−/− | Transplanted in control mice | Reduced neointimal formation after vascular injury | Noma et al., 2008 | |
Rock2 | ||||
BP/endothelial function/hypertension | Rock2+/− | Normal basal systolic BP | Noma et al., 2008 | |
Reduced basal systolic BP | Yao et al., 2013 | |||
Increased NO production and endothelial-dependent relaxation | ||||
Reduction of diabetes-induced rise in BP and endothelial dysfunction | ||||
Atherosclerosis | Bone marrow Rock2−/− | Transplanted in Ldlr−/− mice | Reduced atherosclerosis | Zhou et al., 2012 |
Reduced lipid accumulation | ||||
Reduced macrophage cholesterol efflux | ||||
Neointimal thickening | Rock2+/− | No change in intimal formation after vascular injury | Noma et al., 2008 | |
PAH | SM-Rock2+/− | Reduced PAH | Shimizu et al., 2013 | |
Reduced vascular smooth muscle cell proliferation | ||||
TgSM-Rock2 | Increased PAH | Shimizu et al., 2013 | ||
Increased vascular smooth muscle cell proliferation |
BP, blood pressure.