TABLE 1

Effects of N/OFQ, injected into discrete brain regions, or of a NOP-receptor agonist administered systemically, on the function of the dopaminergic nigro-striatal projection in rats

TreatmentResult
N/OFQ, into SNr1) reduced firing of SNc DA neurons; effect blocked by UFP-101 or J113397 (Marti et al., 2004)
โ€œ2) reduced release of DA into microdialysates of dorsal striatum; effect blocked by UFP-101 (Marti et al., 2004)
โ€œ3) reduced rat motor performance on rotarod; UFP-101 improved performance (Marti et al., 2004)
โ€œ4) increased release of Glu into microdialysates of SNr; blocked by a NOP receptor antagonist (Marti et al., 2002)
N/OFQ, i.c.v.1) stimulated locomotor activity at a low doses (10 ng), reduced activity at high dose (10ยตg) ; stimulatory effect reduced by both D1 and D2 antagonists (Florin et al., 1996)
N/OFQ, i.c.v.2) dose-dependently reduced L-DOPA-induced dyskinesia in 6-OHDA rats; effect blocked by UFP-101 & J113397 (Marti et al., 2012)
N/OFQ, into striatumreduced L-DOPA-induced abnormal involuntary movements (AIMS) in 6-OHDA rats (Marti et al., 2012) (N/OFQ is less potent in reducing AIMS after administration to SNr).
Ro-65-6570 i.p.dose-dependently reduced L-DOPA-induced dyskinesia in 6-OHDA rats; effect blocked by UFP-101 & J113397 (Marti et al., 2012)
  • i.c.v, intracerebroventricular injection; i.p., intraperitoneal administration