Condition | Intervention | Purpose | Phase | Trial Identifier(s) |
---|---|---|---|---|
Infertility | Heparin, LMWH | Heparin increases outcome in poor responders undergoing in vitro fertilization (implantation and clinical pregnancy rates) | 2 and 3 | NCT02144064, NCT01924104, NCT01214772 2011-003080-30, 2011-002219-28 |
Antiphospholipid syndrome and pregnancy | Heparin, enoxaparin | Treatment of recurrent pregnancy loss associated with antiphospholipid syndrome | 2 | NCT01051778 |
Assisted reproductive technology | Enoxaparin | Topical application of heparin to improve intracytoplasmic sperm injection | 2 | NCT02325479 |
Hemodialysis | Heparin | Evaluate if topically applied heparin aids construction of primary arteriovenous fistulas | 2 | NCT01382888, 2011-000455-16 |
Inhalation burns, smoke inhalation injury | Heparin | Efficacy of nebulized heparin on lung injury score in inhalation burn injury over normal care (HEPBURN) | 2 | NTC01773083, 2012-003289-42 |
Lung cancer | Tinzaparin/enoxaparin | LMWH can inhibit tumor growth and metastasis and enhance survival of patients | 3 | NCT00475098, NCT00771563, 2007-007696-16 |
Inflammation | Enoxaparin, heparin | Treatment of inflammation in intraocular lens implantation, cataract surgery, and chronic glomerulonephritis | 3 and 4 | NCT00986076, NCT00001311, 2005-002989-11 |
Adenocarcinoma of the colon | Tinzaparin | LMWH reduction of metastases and recurrence in patients as seen in animal models | 3 | NCT01455831 |
Breast, colorectal, lung, prostate and veno-occlusive cancers | Dalteparin, nadroparin, enoxaparin | Assess whether LMWH beyond inhibition of thrombosis improves quality of life/survival rate over standard chemotherapy treatment | 2 and 3 | NCT00003674, NCT00718354, NCT00717938, 2005-005336-27, 2007-002608-16 |
Supratentorial glioblastoma multiforme | Dalteparin | Heparin may stop the growth of cancer stopping blood flow and blocking enzymes in tumor growth | 2 | NCT00028678 |
Vulvodynia | Enoxaparin | LMWH may reduce pain in women with vulvodynia | 2 | NCT00874484 |
Ulcerative colitis | Deligoparin | Ultra-LMWH may help to reduce inflammation in ulcerative colitis | 2 and 3 | NCT00033943, 2006-001782-42 |
Diabetic foot ulcers | Dalteparin | Treatment on chronic foot ulcers due to peripheral arterial occlusive disease in patients with diabetes | 2 and 3 | NCT00765063, NCT00662831 |
Ovarian cancer | Dalteparin | To improve morbidity and mortality when used in conjunction with standard therapy | 2 | NCT00239980 |
Pediatric solid tumors, acute myeloid leukemia | ODSH | Treatment with heparin to increase platelet recovery time after chemotherapy | 1 | NCT02164097, NCT02056782 |
Metastatic pancreatic cancer | ODSH, dalteparin | Determine if ODSH or dalteparin is efficacious in patients receiving normal therapy | 2 | NCT01461915, NCT00462852 |
Metastatic kidney cancer | Tinzaparin | Prevention of growth in inoperable cancer | 1 and 2 | NCT00293501 |
Pregnancy complications | Enoxaparin, dalteparin | Evaluate efficacy of LMWH on pregnancy outcome in women with previous pregnancy complications | 3 | 2006-004205-26, 2005-005850-30, 2008-005705-19, NCT01388322, NCT00400387 |
Burns | Heparin | Assess analgesic effect of heparin in topical and parenteral treatment | 2 | 2007-004304-12 |
Cystic fibrosis | Heparin | Nebulized heparin on easing cystic fibrosis | 2 | 2007-006276-11 |
Pulmonary conditions | Heparin, desulfated heparin | Improve lung function in obstructive pulmonary conditions | 2 | 2006-006378-32, 2010-024168-16 |
Acute chest syndrome | Heparin | Improve clinical outcome, and decrease hospitalization | 2 | NCT02098993 |
Labor | Non-anticogualant LMWH | Reducing prolonged labor | 2 | 2006-005839-20 |
Microalbuminuria | Sulodexide (LMWH and dermatan sulfate) | Treat microalbuminuria in type 2 diabetes | 3 | 2005-003158-91 |
Data are from taken from the US National Institutes of Health ClinicalTrials.gov database (http://www.clinicaltrials.gov) and the EU Clinical Trials Register (http://www.clinicaltrialsregister.eu) in December 2014. ODSH, O-desulfated heparin.