Drug | Animal Laboratory | Human Laboratory | Clinical Trials |
---|---|---|---|
Drugs that Target Monoamine Transporters | |||
d-Amphetamine | ⇓(9/12) | ⇓(1/1) | ⇓(4/4) |
Methylphenidate | −(0/2) | ⇓(1/1) | −(1/3) |
Modafinil | ⇓(1/1) | ⇔(1/2) | −(2/7) |
Desipramine | −(0/1) | −(0/1) | ⇔(1/2) |
Amantadine | −(0/1) | −(0/1) | −(1/3) |
Drugs that Facilitate GABA Function | |||
Baclofen | ⇔(5/8) | ⇔(1/2) | ⇔(1/2) |
Tiagabine | −(0/1) | −(0/1) | −(0/2) |
Drugs that Target Other Mechanisms | |||
Buspirone | −(1/5) | -(0/1) | −(0/2) |
Buprenorphine | ⇓(6/8) | ⇓(2/2) | ⇔(2/4) |
Progesterone | ⇓(1/1) | −(0/1) | −(0/1) |
⇓, Drug selectively reduced cocaine taking in majority of reviewed studies. ⇔, Drug had mixed effects on cocaine taking across reviewed studies. −, Drug had no selective effect on cocaine taking in majority of reviewed studies.