Effect of reviewed drugs on cocaine taking
Parentheses indicate the number of studies showing significant (and, in animal studies, selective) reductions in cocaine taking (numerator) out of total reviewed studies (denominator).
| Drug | Animal Laboratory | Human Laboratory | Clinical Trials |
|---|---|---|---|
| Drugs that Target Monoamine Transporters | |||
| d-Amphetamine | ⇓(9/12) | ⇓(1/1) | ⇓(4/4) |
| Methylphenidate | −(0/2) | ⇓(1/1) | −(1/3) |
| Modafinil | ⇓(1/1) | ⇔(1/2) | −(2/7) |
| Desipramine | −(0/1) | −(0/1) | ⇔(1/2) |
| Amantadine | −(0/1) | −(0/1) | −(1/3) |
| Drugs that Facilitate GABA Function | |||
| Baclofen | ⇔(5/8) | ⇔(1/2) | ⇔(1/2) |
| Tiagabine | −(0/1) | −(0/1) | −(0/2) |
| Drugs that Target Other Mechanisms | |||
| Buspirone | −(1/5) | -(0/1) | −(0/2) |
| Buprenorphine | ⇓(6/8) | ⇓(2/2) | ⇔(2/4) |
| Progesterone | ⇓(1/1) | −(0/1) | −(0/1) |
⇓, Drug selectively reduced cocaine taking in majority of reviewed studies. ⇔, Drug had mixed effects on cocaine taking across reviewed studies. −, Drug had no selective effect on cocaine taking in majority of reviewed studies.