TABLE 5

N-hydroxysuccinimide derivative inhibitors blocking human PR3 activity

Embedded Imagekobs/[I]
PR3Elastase
M−1s−1
R1R2
n-PropylMethyl8600a8600b
Isopropyltrans-Styryl8100a100,000b
Isobutyltrans-Styryl10,400aN.D.c

  • ↵a Values from Groutas et al. (1990).

  • ↵b Values from Groutas et al. (1989).

  • ↵c Inactivation was too fast to measure by sampling techniques (Groutas et al., 1989).