1978 | Identification of PR3 as the third elastase-like protease | Baggiolini et al., 1978 |
1988 | Elastolytic activity of PR3 showed in vivo | Kao et al., 1988 |
1989 | Role of PR3 in cell differentiation attributed | Bories et al., 1989 |
1990 | First synthetic inhibitors of PR3 reported | Groutas et al., 1990 |
| cDNA cloning of PR3 performed | Campanelli et al., 1990 |
| PR3 identified as the target antigen for C-ANCA | Jenne et al., 1990 |
| PR3 detected on the neutrophil cell surface | Csernok et al., 1990 |
1991 | First biochemical and enzymatic characterization of PR3 performed | Rao et al., 1991 |
| Inhibition of PR3 by elafin investigated | Wiedow et al., 1991 |
1992 | Gene mapping of PR3 performed | Sturrock et al., 1992 |
| Substrate binding site of PR3 mapped using synthetic substrates and inhibitors | Brubaker et al. Kam et al., 1992a,b |
1993 | PR3 gene (PRTN3) localized on 19p13.3 | Sturrock et al., 1993 |
| Interaction of PR3 with SLPI investigated | Rao et al., 1993 |
1995 | Bimodal distribution of PR3 on resting neutrophil surface observed | Halbwachs-Mecarelli et al., 1995 |
1996 | Recombinant production of PR3 in human mast cell line-1 cells as active enzyme performed | Specks et al., 1996 |
| Crystal structure of PR3 identified | Fujinaga et al., 1996 |
1999 | PR3 detected in secretory vesicles | Witko-Sarsat et al., 1999 |
| Mouse anti-PR3 mAbs were characterized and four separate epitopes areas on PR3 were identified | Van der Geld et al., 1999 |
2004 | CatC identified as its endogenous activator | Pham et al., 2004 |
| Role of PR3 in cell apoptosis attributed | Pendergraft et al., 2004 |
| First selective FRET substrates of PR3 developed | Korkmaz et al., 2004 |
2005 | PR3 is colocalized with FcγRIIIB in neutrophil lipid raft | David et al., 2005 |
2007 | NB1 (CD177) is identified as a PR3m receptor | von Vietinghoff et al., 2007 |
2008 | Unique hydrophobic cluster of PR3 identified as its membrane binding area | Korkmaz et al., 2008a |
2009 | Enzymatic characterization of PR3m performed | Korkmaz et al., 2009 |
| PR3 is identified on neutrophil extracellular traps | Kessenbrock et al., 2011 |
2010 | Conformational epitopes of PR3 mapped | Kuhl et al., 2010 |
| | Silva et al., 2010 |
2011 | First recombinant selective protein inhibitor of PR3 developed: serpinB1(STDA/R) | Jégot et al., 2011 |
2012 | First cell-permeable FRET substrate of PR3 synthesized | Wysocka et al., 2012 |
| First synthetic substrate-like inhibitor of PR3 developed: azapro-3 | Epinette et al., 2012 |
2013 | First mAb completely altering activity of PR3 identified: MCPR3-7 | Hinkofer et al., 2013 |
2014 | First PR3 activity-based probe developed | Guarino et al., 2014 |
| Altered conformation and activity of PR3m reported | |
2015 | Allosteric modulation of PR3 activity by C-ANCA reported | Hinkofer et al., 2015 |
| Endothelial cytoskeletal target substrates of PR3 identified | Jerke et al., 2015 |