AMPA/kainate | | | | | |
Cocaine | CNQX | Competitive antagonist | Systemic | Inhibited cue-induced reinstatement | Bäckström and Hyytiä, 2003 |
| NBQX | Antagonist | Systemic | Inhibited cue-induced reinstatement | Zavala et al., 2008 |
| DNQX | Antagonist | Systemic | Inhibited CPP | Kaddis et al., 1995 |
| CNQX | Competitive antagonist | NAcore | Inhibited sensitized locomotor response | Pierce et al., 1996 |
| CNQX | Competitive antagonist | NAcore | Inhibited cocaine intake | Suto et al., 2009 |
| CNQX | Competitive antagonist | NAcore | Inhibited cocaine intake in extended access | Doyle et al., 2014 |
| CNQX | Competitive antagonist | NAcore | Inhibited cue-induced reinstatement | Bäckström and Hyytiä, 2007 |
| CNQX | Competitive antagonist | NAcore | Inhibited context-induced reinstatement | Xie et al., 2012 |
| CNQX | Competitive antagonist | NAcore | Inhibited drug-primed reinstatement | Cornish and Kalivas 2000 |
| LY293558 | GluR5 AMPA/kainate antagonist | NAcore | Inhibited cue-induced reinstatement | Di Ciano and Everitt, 2001 |
| AMPA | Agonist | NAshell | Promoted cocaine seeking | Ping et al., 2008 |
| Naspm | Antagonist of GluA2-lacking AMPA | NAcore / NAshell | Inhibited incubation of cocaine craving | Conrad et al., 2008 |
Opiates | CNQX | Competitive antagonist | NAcore | Inhibited cue-induced and drug-primed reinstatement | Lalumiere and Kalivas, 2008 |
Ethanol | CNQX | Competitive antagonist | Systemic | Inhibited cue-induced reinstatement | Bäckström and Hyytiä, 2004 |
Amphetamines | DNQX | Antagonist | Systemic | Inhibited CPP | Miyatake et al., 2005 |
| DNQX | Antagonist | Systemic | Inhibited sensitized locomoter response | Karler et al., 1991 |
| CNQX | Competitive antagonist | Accumbens | Inhibited sensitized locomoter response | Burns et al., 1994 |
NMDA | | | | | |
Cocaine | MK-801 | Uncompetitive antagonist | Systemic | Inhibited drug-primed CPP | Brown et al., 2008 |
| MK-801 | Uncompetitive antagonist | Systemic | Promoted drug-primed reinstatement | De Vries et al., 1998 |
| Acamprosate | NMDA antagonist, GABA receptor agonist | Systemic | Inhibited cue-induced and drug-primed reinstatement | Bowers et al., 2007 |
| Acamprosate | NMDA antagonist, GABA receptor agonist | Systemic | Inhibited CPP | McGeehan and Olive, 2003a |
| Acamprosate | NMDA antagonist, GABA receptor agonist | Systemic | Inhibited reinstatement of CPP | McGeehan and Olive, 2006 |
| Memantine | Antagonist | Systemic | Inhibited CPP | Kotlińska and Biała, 2000 |
| AP5 | Competitive antagonist | NAcore | Inhibited sensitized locomoter response | Pulvirenti et al., 1994 |
| AP5 | Competitive antagonist | NAcore/NAshell | Promoted cocaine-conditioned locomotion | Rodríguez-Borrero et al., 2006 |
| AP5 | Competitive antagonist | NAcore/NAshell | Promoted cocaine seeking | Famous et al., 2007 |
| AP5 | Competitive antagonist | NAcore | Inhibited cue-induced reinstatement | Bäckström and Hyytiä, 2007 |
Nicotine | MK-801 | Uncompetitive antagonist | Systemic | Inhibited sensitized locomoter response | Shoaib and Stolerman, 1992 |
| Acamprosate | NMDA antagonist, GABA receptor agonist | Systemic | Inhibited cue-induced reinstatement | Pechnick et al., 2011 |
| Memantine | Antagonist | Systemic | Inhibited intake | Blokhina et al., 2005 |
Opiates | Acamprosate | NMDA antagonist, GABA receptor agonist | Systemic | Inhibited sensitized locomoter response | Spanagel et al., 1998 |
| Memantine | Antagonist | Systemic | Inhibited CPP | Ribeiro Do Couto et al., 2004 |
| Ifenprodil | Antagonist of GluN2B-containing receptors | Systemic | Inhibited cue-induced and drug-primed reinstatement | Shen et al., 2011 |
| Ifenprodil | Antagonist of GluN2B-containing receptors | Systemic | Inhibited CPP | Suzuki et al., 1999 |
| Ifenprodil | Antagonist of GluN2B-containing receptors | NAcore | Inhibited cue-induced and drug-primed reinstatement | Shen et al., 2011 |
Ethanol | Acamprosate | NMDA antagonist, GABA receptor agonist | Systemic | Inhibited CPP | McGeehan and Olive, 2003a |
| Acamprosate | NMDA antagonist, GABA receptor agonist | Systemic | Inhibited intake and CPP | Olive et al., 2002 |
| AP5 | Competitive antagonist | Accumbens | Inhibited intake | Rassnick et al., 1992 |
Amphetamines | MK-801 | Uncompetitive antagonist | Systemic | Inhibited CPP | Tzschentke, 2007 |
| Ifenprodil | Antagonist of GluN2B-containing receptors | Systemic | Inhibited CPP | Miyatake et al., 2005 |
| AP5 | Competitive antagonist | Accumbens | Decreased potentiation of conditioned reinforcement | Burns et al., 1994 |