Diterpene | AC1 | AC2 | AC5 | 5C1:2C2 | ||||
---|---|---|---|---|---|---|---|---|
EC50 | Efficacy | EC50 | Efficacy | EC50 | Efficacy | EC50 | Efficacy | |
μM | % | μM | % | μM | % | μM | % | |
FSK | 3.3 | 100 | 38 | 100 | 18 | 100 | 7.4 | 100 |
DMB-FSK | 2.8 | 65 | 50 | 46 | 11 | 81 | 28 | 41 |
6A7DA-FSK | 3.0 | 110 | 17 | 70 | 13 | 70 | 2.6 | 83 |
7DA-FSK | 9.3 | 109 | 81 | 62 | 38 | 124 | 3.1 | 86 |
9d-FSK | 17 | 98 | 127 | 30 | 61 | 108 | 20 | 79 |
1d-FSK | N.D. | 3 | N.D. | 0.4 | N.D. | 0.7 | ine. | ine. |
BODIPY-FSK | 1.2 | 73 | 0.2 | −19 | 2.7 | 69 | N.D. | N.D. |
N.D., not determined. Ine., ineffective. Structures of diterpenes are shown in Fig. 12. FSK, forskolin; DMB, 7-deacetyl-7-(N-methylpiperazino-butyryloxy); 6A7DA, 6-acetyl-7-deacetyl; 7DA, 7-deacetyl; 9d, 9-deoxy; 1d, 1-deoxy; BODIPY, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene.