Cpd. | Inhibitor | AC1 | AC2 | AC5 | 5C1:2C2 | sAC | sGC α1β1 (GC1a) |
---|---|---|---|---|---|---|---|
1 | MANT-ATP | 6.82b | 6.48b | 7.00b | 7.80b | 5.25c | 6.77 |
2 | MANT-ITP | 8.55b | 7.85b | 8.92b | 9.15b | N.D. | 6.31 |
3 | MANT-GTP | 7.05b | 6.21b | 7.28b | 7.74b | >4.00c | 6.06 |
4 | MANT-XTP | 5.96b | 5.52b | 5.89b | 5.92b | N.D. | 6.95 |
5 | MANT-CTP | 6.82b | 6.16b | 6.82b | 8.04b | N.D. | 6.28 |
6 | MANT-UTP | 7.34b | 6.34b | 7.49b | 8.21b | N.D. | 6.30 |
7 | 2’-MANT-3′-dATP | 6.33b | 6.27b | 7.19b | 7.05b | 4.60c | 7.78 |
8 | 3′-MANT-2’-dATP | 6.49b | 5.32b | 6.44b | 6.72b | N.D. | 6.13 |
9 | MANT-ATPγS | 6.80d | 6.42d | 7.11d | N.D. | N.D. | 6.88 |
10 | MANT-ITPγS | 7.39c | 6.92c | 7.51c | 7.72b | >4.00c | 6.03 |
11 | MANT-GTPγS | 7.21c | 6.44c | 7.46c | 7.62b | >4.00c | 6.33 |
12 | ANT-ATP | 6.89b | 6.19b | 6.92b | 7.77b | N.D. | 6.63 |
13 | Cl-ANT-ATP | 7.10e | 6.31e | 7.35e | N.D. | N.D. | 7.33 |
14 | Cl-ANT-ITP | 8.48e | 8.10e | 8.70e | N.D. | N.D. | 5.92 |
15 | Br-ANT-ITP | 8.15e | 7.66e | 8.34e | N.D. | N.D. | 6.22 |
16 | Pr-ANT-ATP | 6.36e | 5.96e | 6.44e | N.D. | N.D. | 6.80 |
17 | Pr-ANT-ITP | 7.66e | 7.17e | 8.00e | N.D. | N.D. | 6.41 |
18 | AcNH-ANT-ATP | 5.17e | 4.96e | 5.47e | N.D. | N.D. | 6.11 |
19 | AcNH-ANT-ITP | 6.85e | 6.41e | 7.43e | N.D. | N.D. | 6.22 |
20 | MANT-AppNHp | 6.80c | 6.31c | 6.92c | 7.70c | 5.72c | 6.77 |
21 | MANT-GppNHp | 6.96c | 6.18c | 7.01c | 7.47c | N.D. | 5.56 |
22 | TNP-ATP | 8.05f | 7.00f | 8.43f | 7.09g | 6.19f | 7.67 |
23 | TNP-GTP | 7.64f | 6.66f | 7.57f | 7.08g | 5.14f | 7.97 |
24 | TNP-CTP | 7.62f | 6.96f | 7.51f | 6.51g | 5.29f | 7.01 |
25 | TNP-UTP | 8.15f | 7.62f | 7.82f | 7.04g | 5.51f | 7.29 |
26 | Bis-MANT-ATP | 6.15e | 5.68e | 6.37e | N.D. | N.D. | 6.23 |
27 | Bis-MANT-ITP | 6.51e | 5.96e | 6.85e | N.D. | N.D. | 6.46 |
28 | Bis-MANT-CTP | 6.21e | 5.11e | 6.12e | N.D. | N.D. | 6.10 |
29 | Bis-MANT-IDP | 6.00e | 5.85e | 6.15e | N.D. | N.D. | 5.72 |
30 | Bis-MANT-IMP | <3e | <3e | <3e | N.D. | N.D. | <3 |
31 | Bis-Cl-ANT-ATP | 5.77e | 5.62e | 5.80e | N.D. | N.D. | 6.28 |
32 | Bis-Cl-ANT-ITP | 7.18e | 6.70e | 7.19e | N.D. | N.D. | 6.08 |
33 | Bis-Br-ANT-ATP | N.D. | N.D. | N.D. | N.D. | N.D. | 6.37 |
34 | Bis-Br-ANT-ITP | 7.68e | 7.15e | 7.82e | N.D. | N.D. | 6.20 |
35 | Bis-Pr-ANT-ATP | 4.74e | 4.44e | 4.74e | N.D. | N.D. | 5.44 |
36 | Bis-Pr-ANT-ITP | 6.36e | 5.85e | 6.60e | N.D. | N.D. | 5.91 |
37 | Bis-AcNH-ANT-ATP | 4.66e | 5.15e | 5.21e | N.D. | N.D. | 5.41 |
38 | Bis-AcNH-ANT-ITP | 5.77e | 5.25e | 6.32e | N.D. | N.D. | 5.97 |