TABLE 6

Toxicity of BoNTs in mice upon i.p. injection expressed as LD₅₀ (ng/kg)

Toxin Type	LD₅₀	Reference
BoNT/A1	1.15^{^a}	Duff, et al., 1957a
	0.45	Nakamura et al., 2010
	0.38	Pier et al., 2011
	0.40	Whitemarsh et al., 2013
	0.40	Pellett et al., 2015b
	0.25	Azarnia Tehran et al., 2015
BoNT/A2	0.11	Pier et al., 2011
BoNT/A2	0.39	Whitemarsh et al., 2013
BoNT/A3	0.35	Whitemarsh et al., 2013
BoNT/A4	400–500	Whitemarsh et al., 2013
BoNT/A5	0.35	Whitemarsh et al., 2013
BoNT/B1	1.93^{^a}	Lamanna and Glassman, 1947
	1.23^{^a}	Duff, et al., 1957b
	0.41	Nakamura et al., 2010
	0.45^{^b}	Azarnia Tehran et al., 2015
BoNT/B2	0.40	Fan et al., 2016
BoNT/C1	5.00	Notermans et al., 1982
	2.30	Tsukamoto et al., 2005
	1.65	Morbiato et al., 2007
	0.92	Nakamura et al., 2010
BoNT/CD	1.42	Notermans et al., 1982
	1.80	Matsuda et al., 1986
	1.92	Tsukamoto et al., 2005
	0.80	Nakamura et al., 2010
BoNT/D	0.15	Tsukamoto et al., 2005
	0.18	Nakamura et al., 2010
	0.83	Eleopra et al., 2013
	0.43	Pellett et al., 2015b
	0.02^{^b}	Azarnia Tehran et al., 2015
BoNT/DC	0.05	Nakamura et al., 2010
BoNT/E1	0.65	Pier et al., 2011
	0.84	Chatla et al., 2012
	1.00	Meunier et al., 2003
BoNT/F1	2.50	Oishi and Sakaguchi, 1974
BoNT/F1	10.0	Meunier et al., 2003
BoNT/FA	2.20	Fan et al., 2016
BoNT/FA	1.30	Maslanka et al., 2016
BoNT/G	5.00	Schiavo et al., 1994

↵^a BoNT complexed as PTC.
↵^b Toxins produced by recombinant methods.