TABLE 5

Therapeutic uses for botulinum neurotoxin

Ophtalmology
 Strabismusa,b,c
 Nistagmus
Neurology
 Focal Dystonias
  Blepharospasma,b,c
  Cervical dystoniaa,b,c (Torticollis, anterocollis, laterocollis)
  Occupational dystonias (writer’s crampb, musician’s cramps)
  Laryngeal Dysphoniac
  Oromandibular dystonia
  Lingual dystonia
 Nondystonic disorders
  Hemifacial spasma,b,c
  Tremor (essential, parkinsonism)
  Tics
  Bruxism
 Spasticity (poststroke, multiple sclerosis, brain or spinal cord injury)
  Focal spasticitya,b,c: Upper and lower limb spasticity
  Nonfocal: hemispasticity, paraspasticity, tetraspasticity
  Cerebral palsyab
 Hyperhidrosisa,b,c
  Focal: axillary, palmar, plantar
  Diffuse
 Hypersalivation
  Sialorrheab (motoneuron diseases/amyotrophic lateral sclerosis)
  Droolingb (Parkinsonian syndromes)
  Frey’s syndrome/gustatory sweating
 Aesthetic (muscle)
  Glabellar rythidesa,b,c
Pain
 Muscular
  Dystonia
  Spasticity
  Chronic myofascial pain
  Temporomandibular disorders
  Low back pain
 Nonmuscular
  Migraine (chronica and tension type migraine)
  Neuropathic pain
  Trigeminal pain
  Pelvic pain
Urology
 Detrusor sphincter dyssynergia
 Overactive bladdera,b,c (Idiopathic or neurogenic detrusor  overactivity)
 Urinary retention
 Bladder pain syndrome
 Pelvic floor spasms
 Benign prostate hyperplasia
Gastroenterology
 Achalasia
 Chronic anal fissures
Psychiatry
 Depressiond
  • a USA approved indication.

  • b EU approved indication.

  • c Evidence-based therapeutic indication.

  • d To be evaluated.