TABLE 3

Sequence alignment of mouse, rat, and human Syntaxin isoforms and cleavage site of BoNTs

The C-terminal SNARE motifs of mouse, rat, and human syntaxin isoforms are aligned using http://www.uniprot.org/align/. BoNT/C conserved cleavage sites are shown in purple. Conserved cleavage sites whose susceptibility to cleavage is predicted, but not experimentally proven, are underlined in purple. Nonconserved cleavage sites are underlined in black.