TABLE 3

Structures of HCN channel C-terminal domain deposited in the Protein Data Bank (PDB) up to November 2016

PDB CodeIsoform (Residues)LigandReferences
1Q43mHCN2 (443–640)cAMPZagotta et al. (2003)
1QE3mHCN2 (443–645)cGMPZagotta et al. (2003)
1Q5OmHCN2 (443–645)cAMPZagotta et al. (2003)
2PTMSpHCN (470–665)cAMPFlynn et al. (2007)
3BPZmHCN2 (443–640)acAMPCraven et al. (2008)
3ETQmHCN2(443–640)bcAMPTaraska et al. (2009)
3FFQmHCN2Br−Taraska et al. (2009)
3OTFhHCN4 (521–739)cAMPXu et al. (2010)
3UOZHCN1 (390–592)cAMPLolicato et al. (2011)
3U10mHCN2 (470–672)cAMPLolicato et al. (2011)
3U11hHCN4 (521–723)cAMPLolicato et al. (2011)
4EQFmHCN2 (857–863)Trip8b (206–567)Bankston et al. (2012)
4HBNhHCN4 (521–724)ccAMPXu et al. (2012)
4NVPhHCN47CH-cAMPMöller et al. (2014)
4KL1hHCN4 (521–723)cGMPLolicato et al. (2014)
5KHGmHCN2 (443–643)cCMPNg et al. (2016)
5KHHmHCN2 (443–643)cIMPNg et al. (2016)
5KHImHCN2 (443–643)cPMPNg et al. (2016)
5KHJmHCN2 (443–643)cUMPNg et al. (2016)
5KHKmHCN2 (443–643)2-NH2-cPMPNg et al. (2016)
2MNGHCN4–—Akimoto et al. (2014)
2MPFHCN2—Saponaro et al. (2014)

  • Mutations: aE502K; bC508N, C584S, C601S; cS672R.