CNS effects of cytokines dependent on their transport across the BBB
| Cytokine | Effect | Reference |
|---|---|---|
| IL-1 | Impairs cognition | Banks et al., 2001a |
| IL-1ra | Improves stroke outcome | Zhang et al., 2017a |
| FGF | Protects against ischemia-reperfusion injury | Cuevas et al., 1998 |
| FGF | TBI protection | Sun et al., 2009 |
| FGF | Stimulation of neurogenesis | Wagner et al., 1999 |
| TNF | Induction of Parkinson’s-like symptoms | Qin et al., 2007 |
| TNF | Chemobrain | Joshi et al., 2010 |
| Orexin | Improved septic shock survival | Kastin and Akerstrom, 1995; Ogawa et al., 2016 |
FGF, fibroblast growth factor; TBI, total body irradiation.