TABLE 3 

Interactions between caffeine and antiepileptic drugs (AEDs)

Data according to Czuczwar et al. (1990), Wlaz et al. (1992), Gasior et al. (1996, 1998), Vaz et al. (1998), Zuchora et al. (2005), Luszczki et al. (2006), Jankiewicz et al. (2007), Chrościńska-Krawczyk et al. (2009, 2016), Walzer et al. (2012).

AnticonvulsantSpeciesType of Interaction
Classic AEDs
CarbamazepineRats, miceAcute and chronic caffeine dose-dependently decrease efficacy
CarbamazepineHumansIncreases half-life by twofold; decreases bioavailability by 32%
ClobazamHumansNo significant action on clobazam pharmacokinetics
No interactions between clobazam and valproate or lamotrigine
ClonazepamRatsNo significant effect
DiazepamMiceDecrease in efficacy
DiphenylhydantoinMiceDecrease in efficacy
EthosuximideRatsDecrease in efficacy
PhenobarbitalRatsNo significant effect
MiceDecrease in efficacy
PhenytoinMiceDecrease in efficacy
ValproateRatsNo significant effect
MiceDecrease in efficacy
Second generation AEDs
FelbamateMiceNo significant effect, decreased efficacy only at very high doses (100–160 mg/kg caffeine)
GabapentinMiceDecrease in efficacy
LamotrigineMiceNo significant interaction
OxcarbazepineMiceNo significant interaction
TiagabineMiceNo significant interaction
TopiramateMiceDecrease in efficacy