Potential role of the polymorphisms of ADORA2A and adenosine deaminase genes in caffeine-related functions and caffeine consumption
More details can be found in the text.
| Gene | Biologic Role | Clinical Relevance | Replication | Location in Text |
|---|---|---|---|---|
| ADORA2A | Anxiety | Modulation of anxiety levels in response to caffeine intake | Yes | IV.B.1.a |
| Attention | Influence on attentional processing and working memory | Yes | IV.B.1.a | |
| Emotional processing | Influence on startle reflex | Yes | IV.B.1.a | |
| Maladaptive emotional processing | ||||
| Impact on the selection of relevant early information | ||||
| Panic disorder | Extreme reactions to stressful situations | Yes | IV.B.1.a | |
| Agoraphobia | ||||
| Sleep | Susceptibility to hyperarousal-induced insomnia | Yes | IV.B.1.b | |
| Sleep latency | ||||
| Modification of EEG sleep-linked characteristics | ||||
| Caffeine consumption | Carrying the 1976TT genotype decreases caffeine consumption | No | IV.B.1.c | |
| Adenosine deaminase | Sleep | Role in sleep architecture and maintenance | Yes | IV.B.1.b |
| Controls the frequency of awakenings |