TABLE 9

Functional activity (EC50) of endogenous and synthetic agonists of rat, mouse, human, and zebrafish olfactory TAARs

Mammalian TAARSpeciesLigandEC50
μM
TAAR3Rat, mouseCyclohexylamine7 (mouse),b 20 (mouse)c
Isoamylamine10 (mouse)b,c
Octylamine50 (mouse)b
PEA 40 (mouse)b
TAAR4Rat, mousePEA0.7 (mouse),b 1 (mouse)c
TAAR5Human, rat, mouseTrimethylamine0.7 (mouse),b 0.3 (mouse),d 1 (rat),d 0.12 (human)e
N,N-dimethylethylamine1 (mouse),b 0.17 (human)e
N,N-dimethyloctylamine1 (mouse)b
N-methylpiperidine3 (mouse),b 20 (mouse),c >10 (human)e
Pyrrolidine17 (mouse)b
Triethylamine22 (mouse)b
3-pyrroline42 (mouse)b
2-methy-1-pyrroline46 (mouse)b
3ITa4.4 (human)f
TAAR7bRat, mouseN,N-dimethyloctylamine3 (mouse)b
N,N-dimethylbutylamine30 (mouse)b
TAAR7eRat, mouseOctylamine28 (mouse)b
Heptylamine34 (mouse)b
2-methy-1-pyrroline48 (mouse)b
TAAR7dRat, mouseN,N-dimethylcyclohexylamine0.5 (mouse)b
N-methylpiperidine16 (mouse)b
N,N-dimethylbutylamine30 (mouse)b
1-(2-aminoethyl)piperidine30 (mouse)b
Heptylamine33 (mouse)b
2-methy-1-pyrroline50 (mouse)b
TAAR8cHuman, rat, mouseN-methylpiperidine0.5 (rat)g
N,N-dimethylcyclohexylamine13 (rat)g
TAAR9Human, rat, mouseN-methylpiperidine18 (rat)g
N,N-dimethylcyclohexylamine27 (rat)g
Zebrafish TAARs
 TAAR10aZebrafishSerotonin0.5h
5-methoxytryptamine20h
 TAAR10bZebrafishTRP50h
 TAAR12hZebrafishβ-phenyethylamine0.3h
 TAAR13aZebrafishHistamine20h
 TAAR13cZebrafishCadaverine20,i 10h
 TAAR13dZebrafishPutrescine1h
 TAAR16cZebrafishN-methylpiperidine10h
 TAAR16eZebrafishN,N-dimethylcyclohexylamine30h
  • Only compounds with <50 μM activity are listed.

  • a Inverse agonist.

  • b Saraiva et al. (2016).

  • c Liberles and Buck (2006).

  • d Li et al. (2015).

  • e Wallrabenstein et al. (2013).

  • f Dinter et al. (2015c).

  • g Ferrero et al. (2012).

  • h Li et al. (2015).

  • i Hussain et al. (2013).