Final estimates of system parameter half-lives from the meta-analysis (biophase- vs. exposure-driven input)
Data are the CV% and corresponding S.D. for the different parameters.
| Parameter, t1/2 (h) | Lean Sprague-Dawley Rats | Obese Zucker Rats | ||
|---|---|---|---|---|
| DRT Driven | Exposure Driven | DRT Study | Exposure Driven | |
| koutI | 0.03 (16) | 0.11 (14) | 0.04 (45) | 0.06 (17) |
| ktolI | 0.78 (30) | 64. (28) | 4.3 (6.0) | 5.8 (48) |
| koutRI | 0.02 (16) | 0.01 (17) | 28. (54) | 11. (27) |
| kNI | — | — | 5.0 (170) | 29. (35) |
| koutF | 0.001 (1) | 0.002 (140) | 0.002 (150) | 0.004 (120) |
| ktolF | 0.36 (1000) | 0.57 (67) | 1.2 (4.3) | 1.1 (24) |
| koutRF | 0.08 (300) | 0.71 (29) | 77 (58) | 41 (38) |
| kNF | 140 (330) | 110 (65) | 190 (24) | 18 (14) |