Final parameter estimates of first-order and bolus models, their relative S.D. (CV%), and their objective function value (WSSR)
| Parameter | First-Order Biophase Model | Bolus Biophase Model | ||
|---|---|---|---|---|
| Estimate | CV% | Estimate | CV% | |
| Smax | 249 | 1 | 190 | 7 |
| K’ (first-order) (h−1) K (bolus) (h−1) | 5.96 | 4 | 2.54 | 6 |
| SD50 (µg) | 1.02 | 4 | 1.43 | 8 |
| nH | 1.63 | 5 | 2.05 | 18 |
| kout, max (h−1) | 30.1 | 4 | 32.9 | 4 |
| kM (h−1) | 0.001 | 9 | 0.001 | 1 |
| WSSR | 768 | 640 | ||
WSSR, weighted sum of squared residuals.